| nixonix | theres some organization of pediatrics (in uk? not sure) opposing vaccination of children. ill like later or another day about it, if i find more information. but american pediatrics think at least 12+ should be vaccinated | 00:01 |
|---|---|---|
| nixonix | .title https://services.aap.org/en/news-room/news-releases/aap/2021/statement-following-cdc-acip-meeting-from-nations-leading-doctors-nurses-and-public-health-leaders/ | 00:01 |
| Brainstorm | nixonix: From services.aap.org: All AAP | AAP | 00:01 |
| nixonix | pediatricians | 00:01 |
| nixonix | https://twitter.com/RCPCHtweets/status/1417190410573783046 | 00:12 |
| LjL | nixonix, there's some value in having historical versions, like that's how i knew it changed from amber to red, it's not like i'd remember | 00:15 |
| LjL | yes, there are wikis with history | 00:15 |
| LjL | but this is a government | 00:15 |
| nixonix | .title https://asia.nikkei.com/Spotlight/Coronavirus/COVID-19-pill-for-at-home-treatment-in-trials-by-Japan-s-Shionogi | 00:17 |
| Brainstorm | nixonix: From asia.nikkei.com: COVID-19 pill for at-home treatment in trials by Japan's Shionogi - Nikkei Asia | 00:17 |
| nixonix | mentioned molnupiravir is EIDD-2801 | 00:21 |
| nixonix | there was some recent news about some mpro inhibitor showing promise, but forgot which one | 00:22 |
| nixonix | .title https://www.wsj.com/articles/covid-19-pill-race-heats-up-as-japanese-firm-vies-with-pfizer-merck-11627205403 https://archive.is/dmiND | 00:23 |
| Brainstorm | nixonix: From www.wsj.com: Covid-19 Pill Race Heats Up as Japanese Firm Vies With Pfizer, Merck - WSJ | 00:23 |
| nixonix | .title https://science.sciencemag.org/content/early/2021/07/19/science.abg5827 | 00:24 |
| Brainstorm | nixonix: From science.sciencemag.org: Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2 | Science | 00:24 |
| nixonix | it was that one mas... someghitn | 00:24 |
| nixonix | nAb wise Coronavac inactivated whole virus vaccine looks about as strong with two doses than pfizer with one dose: | 00:30 |
| nixonix | .title https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(21)00177-4/fulltext | 00:30 |
| Brainstorm | nixonix: From www.thelancet.com: The Lancet | The best science for better lives | 00:30 |
| nixonix | *Comparative immunogenicity of mRNA and inactivated vaccines against COVID-19 | 00:31 |
| nixonix | ...they found in Hong Kong! | 00:31 |
| Brainstorm | New from The Lancet (Online): [Correspondence] Very rare thrombosis with thrombocytopenia after second AZD1222 dose: a global safety database analysis: Since COVID-19 vaccine roll-out, very rare cases of thrombosis with thrombocytopenia syndrome (TTS), which has been referred to as vaccine-induced immune thrombotic thrombocytopenia, have been reported. [... want %more?] → https://is.gd/WQyleP | 00:37 |
| nixonix | australians think its higher: | 00:45 |
| nixonix | .title https://www.health.gov.au/initiatives-and-programs/covid-19-vaccines/is-it-true/is-it-true-does-the-astrazeneca-covid-19-vaccine-cause-blood-clots | 00:45 |
| Brainstorm | nixonix: From www.health.gov.au: Is it true? Does the AstraZeneca COVID-19 vaccine cause blood clots? | Australian Government Department of Health | 00:45 |
| nixonix | "We are employees of AstraZeneca and might have stock or options, or both" | 00:51 |
| nixonix | interestingly, according to australians, its not just for under 65yo (and they are currently trying to get people in western sydney suburbs to get AZ jab, because theres a small outbreak in that area) | 00:54 |
| LjL | nixonix, these guys may be biased employees maybe buuuuuut what's with the australians? | 00:54 |
| LjL | "There is a very low chance of this side effect, which may occur in around 4-6 people in every million after being vaccinated." | 00:54 |
| LjL | 4-6 every million, okay | 00:54 |
| LjL | then "Estimated risk of TTS per 100,000 | 00:54 |
| LjL | AstraZeneca vaccine doses (first dose)" | 00:54 |
| nixonix | *south-west sydney suburbs | 00:54 |
| LjL | <50 years | 00:54 |
| LjL | 00:54 | |
| LjL | 3.1 | 00:54 |
| LjL | 50-59 years | 00:54 |
| LjL | 00:54 | |
| LjL | 2.7 | 00:54 |
| LjL | 60-69 years | 00:54 |
| LjL | 00:54 | |
| LjL | 1.4 | 00:54 |
| LjL | 70-79 years | 00:54 |
| LjL | 00:54 | |
| LjL | 1.8 | 00:55 |
| LjL | 80+ years | 00:55 |
| LjL | 00:55 | |
| LjL | 1.9 | 00:55 |
| LjL | whoops | 00:55 |
| LjL | sorry | 00:55 |
| LjL | but anyway... how is more than 1/100,000 == 6/1,000,000 | 00:55 |
| nixonix | np, thats good ol irc ranting style | 00:55 |
| LjL | yeah well, i've had bots that would ban you for that :P | 00:55 |
| LjL | i should check the amount of newlines before pressing enter but HexChat doesn't make it very obvious | 00:56 |
| LjL | but anyway, how am i supposed to believe material that says "4-6 every million" and then just a moment later it's like "2-3 every 100000"? | 00:56 |
| LjL | they could lie more convincingly ;( | 00:56 |
| Brainstorm | New from ScienceNews: Why the CDC says it’s crucial to start wearing masks indoors again: While unvaccinated people are driving the spread of the coronavirus, vaccinated people infected with the delta variant may also easily transmit it. → https://is.gd/OZe8iZ | 00:58 |
| nixonix | yeah thats about 4x higher when you look at age groups. maybe updated afterwards, and the leading paragraph isnt | 00:58 |
| nixonix | in some semi recent article they said the prevalence of it looks higher than previously thought, but the risk of death smaller | 00:59 |
| nixonix | but those very small case numbers even in sydney sw suburbs, yea ima shoot az right now... | 01:00 |
| nixonix | .title https://www.dailymail.co.uk/news/article-9820883/All-adults-Sydney-recommended-AstraZeneca-vaccine.html | 01:01 |
| Brainstorm | nixonix: From www.dailymail.co.uk: All adults in Sydney recommended to get the AstraZeneca vaccine | Daily Mail Online | 01:01 |
| mpsaro[m] | https://emraustralia.com.au/blogs/news/5g-will-use-the-same-frequencies-as-pain-inflicting-military-weapon | 01:04 |
| nixonix | yup, skin stops 5g frequencies more efficiently than 4g | 01:05 |
| Brainstorm | Updates for Somalia: +43 cases (now 15294), +1 deaths (now 798) since 20 hours ago | 01:06 |
| nixonix | .title https://www.researchsquare.com/article/rs-736157/v1 | 01:11 |
| Brainstorm | nixonix: From www.researchsquare.com: Comparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines | Research Square | 01:12 |
| nixonix | ChAdOx1 nCoV-19 contains significant amounts of host cell protein impurities, including functionally active proteasomes, and adenoviral proteins. In Ad26.COV2.S much less impurities were found. Platelet-factor 4 (PF4) formed complexes with ChAdOx1 nCoV-19 constituents, but not with purified virions from ChAdOx1 nCoV-19 or with Ad26.COV2.S. | 01:13 |
| nixonix | Vascular hyperpermeability was induced by ChAdOx nCoV-19 but not by Ad26.COV2.S.These differences in impurities together with EDTA-induced capillary leakage might contribute to the higher incidence rate of VITT associated with ChAdOx1 nCoV-19 compared to Ad26.COV2.S | 01:14 |
| nixonix | .title https://www.ft.com/content/f76eb802-ec05-4461-9956-b250115d0577 https://archive.is/AQhPW | 01:17 |
| Brainstorm | nixonix: From www.ft.com: Scientists claim to have solved Covid vaccine blood-clot puzzle | Financial Times | 01:17 |
| LjL | mpsaro[m], what does that have to do with COVID? | 01:17 |
| nixonix | btw, those inactivated whole virus vaccines have lots of "impurities" due to mutations in serial passage. does it matter, not sure exp the small risk of reactivating some virions, if its not checked properly (theres been some claims recently that some chinese and or russina vaccines wouldnt be checked properly) | 01:20 |
| Brainstorm | Updates for Reunion: +2616 cases (now 37231), +9 deaths (now 275) since 6 days ago | 01:31 |
| LjL | nixonix, hmm, has that ever happened with inactivated vaccines? i know it can happen with attenuated ones | 01:31 |
| nixonix | hmm, maybe you are right | 01:34 |
| nixonix | due to mutation, that is. but the inactivation can still fail partly | 01:39 |
| nixonix | .title https://www.france24.com/en/live-news/20210428-brazil-says-russian-covid-vaccine-carried-live-cold-virus | 01:40 |
| Brainstorm | nixonix: From www.france24.com: Brazil says Russian Covid vaccine carried live cold virus - France 24 | 01:40 |
| nixonix | .title https://indianexpress.com/article/india/bharat-biotech-covaxin-brazil-7253118/ | 01:41 |
| Brainstorm | nixonix: From indianexpress.com: Brazil regulator flags safety issues in Covaxin production, denies certificate | India News,The Indian Express | 01:41 |
| LjL | > If batches used in the real world were tainted, then "for most people this probably won't be a big deal because adenoviruses are generally not thought of as really important human pathogens," she said. | 01:54 |
| LjL | i think i remember someone here mentioning adenoviruses can be subtly nasty | 01:54 |
| Brainstorm | New from r/WorldNews: worldnews: 'Severe' Covid-19 cases surge in Tokyo during Olympics → https://is.gd/MVFHjJ | 01:58 |
| Brainstorm | Updates for Nigeria: +404 cases (now 171728) since 21 hours ago — Togo: +116 cases (now 15292) since a day ago — Netherlands: +3947 cases (now 1.9 million), +2 deaths (now 17946) since 20 hours ago — United Kingdom: +17908 cases (now 5.7 million), +69 deaths (now 129382) since 20 hours ago | 02:40 |
| Brainstorm | New from Science Daily: How relaxing COVID-19 restrictions could pave the way for vaccine resistance: A new article outlines how relaxing Covid-19 restrictions could pave the way for new vaccine-resistant virus mutations. It describes how we are in an 'arms race' with the virus and how rising cases could provide opportunities for it to evolve into even [... want %more?] → https://is.gd/jTaQE9 | 03:09 |
| Brainstorm | Updates for Aruba: +55 cases (now 11460) since 21 hours ago | 03:11 |
| Brainstorm | Updates for Turkey: +19761 cases (now 5.6 million), +51 deaths (now 51048) since a day ago — Lebanon: +1502 cases (now 557145), +1 deaths (now 7895) since 23 hours ago — Mauritania: +341 cases (now 24349), +4 deaths (now 542) since 21 hours ago | 03:36 |
| Brainstorm | New from r/WorldNews: worldnews: 'Self-confessed vaccine sceptic' dad loses life after catching Covid-19 aged 34 "34, footie coach and dad. Self-confessed vaccine sceptic until he caught Covid, if he could turn back time he would" → https://is.gd/5RDVJe | 04:30 |
| Brainstorm | New from Reddit (test): COVID19: Human rhinovirus infection blocks SARS-CoV-2 replication → https://is.gd/m3a5Wh | 04:50 |
| Brainstorm | Updates for Thailand: +16533 cases (now 543361), +133 deaths (now 4397) since 21 hours ago — United Kingdom: +23786 cases (now 5.8 million), +101 deaths (now 129414) since 22 hours ago — Netherlands: +4936 cases (now 1.9 million) since 22 hours ago — Canada: +971 cases (now 1.4 million) since 22 hours ago | 05:03 |
| Brainstorm | New from The Indian Express: World: Kuwait bans unvaccinated citizens from travelling abroad → https://is.gd/xSbnfU | 05:20 |
| Brainstorm | Updates for Mexico: +17408 cases (now 2.8 million), +484 deaths (now 239079) since 22 hours ago — Guinea-Bissau: +69 cases (now 4281) since a day ago — Belgium: +1333 cases (now 1.1 million), +2 deaths (now 25230) since 22 hours ago | 06:05 |
| Brainstorm | New from This Week In Virology: TWiV 785: COVID-19 Q&A with Dr. Daniel Griffin: In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more. → https://is.gd/skCdGx | 06:11 |
| Brainstorm | Updates for South Korea: +1896 cases (now 193427), +4 deaths (now 2083) since 22 hours ago | 06:30 |
| twomoon | can someone explain to me how mutation is affected by vaccines/vaccinated people ? | 07:18 |
| Brainstorm | Updates for Texas, United States: +12552 cases (now 3.1 million), +41 deaths (now 53078) since 23 hours ago — Pakistan: +4119 cases (now 1.0 million), +46 deaths (now 23133) since 23 hours ago — Tokyo, Japan: +2848 cases (now 203636), +2 deaths (now 2262) since 23 hours ago — Alabama, United States: +2667 cases (now 574737), +9 deaths (now 11492) since 23 hours ago | 07:32 |
| Brainstorm | New from The Indian Express: World: CDC again calls for indoor masks as Delta variant of Covid-19 erupts → https://is.gd/RTaK71 | 07:33 |
| Brainstorm | New from The Indian Express: World: Against the odds, tiny Bhutan rolls out a second round of mass vaccinations → https://is.gd/4Jckhl | 08:25 |
| Brainstorm | Updates for India: +43654 cases (now 31.5 million), +565 deaths (now 421819) since 23 hours ago | 08:34 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | July 28, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/8JWVnd | 09:06 |
| Brainstorm | New from The Indian Express: World: The pandemic hurt these students the most → https://is.gd/rMt9Bi | 09:26 |
| Brainstorm | Updates for Uzbekistan: +843 cases (now 126627), +8 deaths (now 853) since 23 hours ago | 09:36 |
| Brainstorm | New from The Indian Express (Health): Health: World Hepatitis Day 2021: All you should know about Hepatitis B and Covid vaccines → https://is.gd/ygssne | 09:57 |
| Brainstorm | New from StatNews: ‘There is a real cost’: As Covid shows, barring bedside visitors from ICU deprives patients of the best care: “There seems to be this feeling that family is nice-to-have, not essential." But when they’re not around, as has been the case during most of the pandemic, “there is a… → https://is.gd/fxpqDi | 10:38 |
| Brainstorm | Updates for Kerala, India: +22129 cases (now 3.3 million), +156 deaths (now 16326) since a day ago — Meghalaya, India: +710 cases (now 62473), +9 deaths (now 1040) since a day ago | 10:38 |
| Brainstorm | New from BMJ: Introducing BMJ Medicine: The covid-19 pandemic has been accompanied by an explosion in scientific discourse across mainstream media, social media, preprint servers,1 and peer reviewed journals. Alongside the remarkable... → https://is.gd/OVYzkg | 11:19 |
| Brainstorm | Updates for Russia: +45452 cases (now 6.2 million), +798 deaths (now 156178) since a day ago — Armenia: +280 cases (now 229370) since a day ago | 11:40 |
| Brainstorm | New from Reddit (test): CoronavirusUK: COVID-19: UK to give Kenya more than 800,000 doses of Oxford-AstraZeneca coronavirus vaccine → https://is.gd/UguRXL | 11:49 |
| Brainstorm | Updates for Greenland: +16 cases (now 108) since 2 days ago | 12:05 |
| Brainstorm | New from Politico: Aid and development: Blood-clot risk unchanged after second Oxford/AstraZeneca vaccine shot: study → https://is.gd/3tMNhM | 12:10 |
| Brainstorm | Updates for Germany: +1299 cases (now 3.8 million) since 20 hours ago | 12:30 |
| Brainstorm | New from Politico: British politics: Boris Johnson: UK coronavirus ‘pingdemic’ to end on August 16 → https://is.gd/A5weQs | 12:40 |
| joerg | >>theres been some claims recently that some chinese and or russina vaccines wouldnt be checked properly<< I heard about >>someone here mentioning adenoviruses can be subtly nasty<< I at least had a shake from my first AZ jab like never before in last 20 years, neither with flu nor with flu vaccination nor any other cause. I don't like that chimpanzee cold virus concept, however I happiöy got the jab as soon as I been allowed to | 12:58 |
| Brainstorm | New from Politico: British politics: Deaf woman wins court case against UK government over coronavirus briefings → https://is.gd/INaUwo | 13:21 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Pemetrexed Pfizer (previously known as Pemetrexed Hospira UK Limited), pemetrexed, Carcinoma, Non-Small-Cell Lung,Mesothelioma, Date of authorisation: 24/04/2017, Revision: 7, Status: Withdrawn → https://is.gd/6ypxkE | 13:32 |
| Brainstorm | Updates for Finland: +644 cases (now 104495) since 23 hours ago — Austria: +552 cases (now 657501) since a day ago | 13:32 |
| Brainstorm | New from WHO Euro: Supporting the implementation of COVID-19 contact tracing in Ukraine: To help implement a contact tracing programme for COVID-19 in Ukraine, WHO has been providing support, equipment and staff training to the state-run Chernivtsi Oblast Center for Disease Control and Prevention (OCDC) of the Ministry of Health of Ukraine and Odessa [... want %more?] → https://is.gd/S2ObdM | 13:42 |
| Brainstorm | New from r/WorldNews: worldnews: UK starts donating 9 million COVID-19 vaccines overseas → https://is.gd/7e6ta2 | 13:52 |
| joerg | twomoon left :-/ | 13:55 |
| Brainstorm | New from The Indian Express (Health): Life-style: ‘We need to stop making long term plans and focus on ‘today’’: Taapsee Pannu shares biggest pandemic lesson → https://is.gd/jCBNOs | 14:02 |
| Brainstorm | Updates for Laos: +280 cases (now 5434), +1 deaths (now 6) since a day ago | 14:09 |
| Brainstorm | New from r/WorldNews: worldnews: Fiji health staff who test positive for COVID-19 asked to continue working → https://is.gd/45422j | 14:23 |
| Brainstorm | New from Reddit (test): Covid2019: Greece - Father who pressured 35yo son into Pfizer vaccine, asks for explanation after his son dies one week later → https://is.gd/1GgIQ5 | 14:33 |
| Brainstorm | Updates for Malaysia: +17405 cases (now 1.1 million), +143 deaths (now 8551) since a day ago — Iceland: +156 cases (now 7545) since 20 hours ago | 14:34 |
| thirdwhl | hmm | 14:57 |
| finely[m] | <LjL "then "Estimated risk of TTS per "> 1 in 30 000. But the risk decreases with age. | 14:57 |
| Brainstorm | New from The Indian Express: World: COVID: Saudi announces three-year travel ban for citizens visiting ‘red list’ countries, including India → https://is.gd/5k0NXN | 15:04 |
| Brainstorm | New from BMJ: Covid 19: More US institutes, universities, and businesses make masks mandatory as cases rise sharply: President Joe Biden is expected to announce on 29 July a requirement for federal government employees to be vaccinated or to be regularly tested for SARS-CoV-2 as the nation faces a surge in cases of... → https://is.gd/nLbBl3 | 15:35 |
| Brainstorm | Updates for Gambia: +376 cases (now 7709), +4 deaths (now 212) since 3 days ago — Nepal: +2634 cases (now 688307), +33 deaths (now 9791) since 23 hours ago — Switzerland: +771 cases (now 716038) since 23 hours ago | 15:36 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Biogen yanks Alzheimer’s paper from JAMA over edits; Pfizer sees $33.5 billion in Covid-19 vax sales → https://is.gd/cng2cc | 15:46 |
| Brainstorm | Updates for Iraq: +13515 cases (now 1.6 million), +66 deaths (now 18484) since 21 hours ago — Serbia: +332 cases (now 720975) since 23 hours ago | 16:01 |
| Brainstorm | Updates for Bermuda: +15 cases (now 2553) since 4 days ago | 16:38 |
| Brainstorm | New from BBC Health: (news): Covid: No quarantine for fully jabbed US and EU travellers to England → https://is.gd/s60F2j | 16:59 |
| Brainstorm | New from r/WorldNews: worldnews: Something strange is happening in Britain. Covid cases are plummeting instead of soaring. → https://is.gd/Nir79O | 17:09 |
| Brainstorm | New from WebMD: Biden Weighs Vaccine Mandate for Federal Employees: The latest news illustrates the growing concern among top federal health officials about the spread of the highly contagious Delta variant, but that concern must be balanced against the possibility that mandates could fuel further opposition to vaccination. → https://is.gd/iYbhG7 | 17:19 |
| Brainstorm | Updates for Bangladesh: +16230 cases (now 1.2 million), +237 deaths (now 20016) since a day ago — Azerbaijan: +750 cases (now 341933), +3 deaths (now 5014) since a day ago — Canada: +2 deaths (now 26560) since 22 hours ago | 17:41 |
| -RSSBot[LjLmatrix- Feed: Seconda riunione del CITE - Comitato interministeriale per la transizione ecologica ( https://www.governo.it/it/articolo/seconda-riunione-del-cite-comitato-interministeriale-la-transizione-ecologica/17539 ) | 17:58 | |
| Brainstorm | Updates for United Kingdom: +17231 cases (now 5.8 million) since 23 hours ago | 18:05 |
| Brainstorm | Updates for Cuba: +9323 cases (now 358378), +68 deaths (now 2560) since 23 hours ago | 18:30 |
| Brainstorm | New from StatNews: Efficacy of Pfizer/BioNTech Covid vaccine slips to 84% after six months, data show: The efficacy of the Covid-19 vaccine developed by Pfizer and BioNTech fell from 96% to 84% over six months, according to newly releasedata, a decline that could fuel Pfizer’s case… → https://is.gd/4vRKCA | 18:42 |
| LjL-Matrix | How much money did Pfizer put into that study? :p | 18:48 |
| Brainstorm | New from In The Pipeline: One Lost Methyl Group = Huge Amounts of Food Production: I don’t do a lot of posts on plant biochemistry here, but this news is pretty notable, and it illustrates several points that apply across other fields as well. This new paper has as its background the role of a particular methyl group in the structure of RNA [... want %more?] → https://is.gd/Rafjkp | 18:52 |
| nixonix | .title https://www.medrxiv.org/content/10.1101/2021.07.28.21261159v1 | 19:10 |
| Brainstorm | nixonix: From www.medrxiv.org: Six Month Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine | medRxiv | 19:10 |
| nixonix | doesnt this look better than in israel, for those 4-6 months | 19:10 |
| nixonix | ah, prob less or zero indian variant... | 19:11 |
| nixonix | .title https://www.jpost.com/%20israel-pfizer-news/is-israel-or-the-uk-right-when-it-comes-to-covid-19-vaccine-effectiveness-674766 | 19:22 |
| Brainstorm | nixonix: From www.jpost.com: Is Israel or UK right about COVID-19 vaccine effectiveness? - The Jerusalem Post | 19:22 |
| nixonix | The Israeli study showed that for people vaccinated more than six months ago, the effectiveness of the vaccine at stopping coronavirus dropped to as low as 16% | 19:23 |
| Brainstorm | New from The Atlantic: Masks Give Vaccines a Better Fighting Chance: America’s split with masks turned out to be a brief hiatus. After getting their shots in the spring and early summer, many people figured they could dump their face coverings for good—a sentiment the CDC crystallized in May , when the agency gave fully immunized people its [... want %more?] → https://is.gd/lBx5xQ | 19:23 |
| nixonix | A third explanation relates to the level of PCR testing carried out in the two countries. Israel uses a more sensitive or stringent PCR testing regime than the UK | 19:27 |
| nixonix | also mention other reasons like different interval of dosing. good article | 19:28 |
| nixonix | mentions | 19:28 |
| nixonix | but misses that while t-cell numbers were lower with longer interval, the selection was different and it was more skewed towards memory t-cell types. (is this good or bad or somewhere in between, remains to be seen) | 19:31 |
| Brainstorm | Updates for Italy: +5693 cases (now 4.3 million), +15 deaths (now 128010) since a day ago | 19:32 |
| Brainstorm | New from NPR: England And Scotland End Their Coronavirus Quarantine For Vaccinated U.S. Travelers: Fully vaccinated people from the United States and much of Europe will be able to enter England and Scotland without quarantining — a move welcomed by Britain's ailing travel industry. → https://is.gd/RsXDVS | 19:33 |
| nixonix | .title https://insidemedicine.bulletin.com/243910787550177 https://archive.is/15H9z | 19:40 |
| Brainstorm | nixonix: From insidemedicine.bulletin.com: Facebook Bulletin | 19:40 |
| nixonix | not paywalled, but some cookie shit makes it impossible to read with my hardened browser | 19:41 |
| nixonix | * Delta breakthrough cases: rarely deadly but equally contagious | 19:42 |
| nixonix | says similar viral loads found in breakthrough cases than in unvaccinated (compared variant vs variant? i heard that some minority of breakthrough cases had very small viral loads, but most apparently have closer to normal) | 19:44 |
| nixonix | In SARS-CoV, less than 10% of spike proteins are primed, says Menachery, whose lab group has been quantifying the primed spike proteins but is yet to publish this work. In SARS-CoV-2, that percentage rises to 50%. In the Alpha variant, it’s more than 50%. In the highly transmissible Delta variant, the group has found, greater than 75% of spikes | 20:01 |
| nixonix | are primed to infect a human cell | 20:01 |
| nixonix | s1/s2 cut by furin, that is | 20:01 |
| nixonix | Two coronavirus variants, Alpha and Delta, have altered furin cleavage sites. In the Alpha variant, the initial proline amino acid is changed to a histidine (P681H) ; in the Delta variant, it is changed to an arginine (P681R). Both changes make the sequence less acidic, and the more basic the string of amino acids, the more effectively furin | 20:02 |
| nixonix | recognizes and cuts it, says Barclay. | 20:02 |
| nixonix | .title https://www.nature.com/articles/d41586-021-02039-y | 20:07 |
| Brainstorm | nixonix: From www.nature.com: How the coronavirus infects cells — and why Delta is so dangerous | 20:07 |
| nixonix | .title https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/full#.YQE0BQayS2c.twitter | 20:12 |
| Brainstorm | nixonix: From www.cochranelibrary.com: Ivermectin for preventing and treating COVID‐19 - Popp, M - 2021 | Cochrane Library | 20:12 |
| nixonix | Based on the current very low‐ to low‐certainty evidence, we are uncertain about the efficacy and safety of ivermectin used to treat or prevent COVID‐19. The completed studies are small and few are considered high quality. Several studies are underway that may produce clearer answers in review updates | 20:13 |
| nixonix | Overall, the reliable evidence available does not support the use ivermectin for treatment or prevention of COVID‐19 outside of well‐designed randomized trials | 20:13 |
| nixonix | like with HCQ, theres no evidence it has any benefit. that larger RCT for HCQ was waste of resources. the same would be with ivermectin. just give it up... | 20:14 |
| Brainstorm | New from ScienceMag: [Research Articles] Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy: The immature and dysfunctional vascular network within solid tumors poses a substantial obstacle to immunotherapy because it creates a hypoxic tumor microenvironment that actively limits immune cell [... want %more?] → https://is.gd/165Qx4 | 20:15 |
| nixonix | https://twitter.com/richardzussman/status/1420078157357477888 | 20:28 |
| nixonix | not sure, but possibly from here http://www.bccdc.ca/health-info/diseases-conditions/covid-19/data | 20:30 |
| nixonix | https://twitter.com/Pazzarac1/status/1420119566810763270 | 20:32 |
| nixonix | https://twitter.com/OS51388957/status/1419070818244603907 | 20:34 |
| Brainstorm | Updates for Morocco: +9428 cases (now 597876), +27 deaths (now 9665) since a day ago — Eswatini: +539 cases (now 24247), +5 deaths (now 770) since 19 hours ago | 20:35 |
| Brainstorm | New from CIDRAP: COVID-19 Scan for Jul 28, 2021: COVID-19 and shorter lives Persistent COVID symptoms → https://is.gd/a8jBTf | 20:36 |
| nixonix | .title https://www.ktvu.com/news/three-factors-that-could-be-contributing-to-san-franciscos-surge-in-covid-cases | 20:38 |
| Brainstorm | nixonix: From www.ktvu.com: Three factors that could be contributing to San Francisco's surge in COVID cases | 20:38 |
| nixonix | poll released Friday by the Associated Press found among the Americans who still have not been vaccinated 80% said they probably will not get the COVID vaccine. 64% of those unvaccinated do not believe the shots are effective against the coronavirus variants | 20:40 |
| nixonix | anyone knows a good rona channel with active discussion? | 20:56 |
| Brainstorm | Updates for Spain: +250 cases (now 4.4 million) since a day ago | 20:59 |
| nixonix | .title https://www.scientificamerican.com/article/the-crucial-vaccine-benefit-were-not-talking-about-enough1/ | 21:00 |
| Brainstorm | nixonix: From www.scientificamerican.com: The Crucial Vaccine Benefit We're Not Talking about Enough - Scientific American | 21:00 |
| nixonix | yeayeah, but how about viral loads in upper respiratory with 617.2 after vaccination, and how about them after 6 months or more? | 21:01 |
| nixonix | de-facto wb | 21:16 |
| Brainstorm | Updates for France: +27563 cases (now 6.1 million), +39 deaths (now 111794) since 22 hours ago | 21:37 |
| de-facto | nixonix, thanks | 21:37 |
| nixonix | ive pasted some interesting links. imo anyway. that should be in the logs | 21:38 |
| nixonix | ppl usually didnt comment them, so i might be the only one thinking they were interesting, though | 21:39 |
| ublx | they are interesting | 21:40 |
| * ublx devises a new e-currency to pay nixonix for link submissions | 21:40 | |
| de-facto | .title https://www.nature.com/articles/s41586-021-03807-6 | 21:42 |
| Brainstorm | de-facto: From www.nature.com: SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape | Nature | 21:42 |
| nixonix | i thought awhile back, that forums should have by now ways to do micro payments to writers of the comments they like. instead we got likes | 21:42 |
| ublx | well we don't even have likes. unless we do. does matrix have likes? | 21:43 |
| de-facto | nixonix++ | 21:44 |
| nixonix | i was thinking about forums back then. but some irc channels have had doge wallets, so doge rich people sometimes tipped other ircers | 21:45 |
| nixonix | well they had some other crypto currencies too | 21:46 |
| nixonix | .title https://www.nature.com/articles/s41586-021-03817-4 | 21:54 |
| Brainstorm | nixonix: From www.nature.com: Broad sarbecovirus neutralization by a human monoclonal antibody | Nature | 21:54 |
| nixonix | Here, we describe a human monoclonal antibody (mAb), designated S2X259, recognizing a highly conserved cryptic receptor-binding domain (RBD) epitope and cross-reacting with spikes from all sarbecovirus clades. | 21:54 |
| nixonix | S2X259 broadly neutralizes spike-mediated entry of SARS-CoV-2 including the B.1.1.7, B.1.351, P.1, B.1.427/B.1.429 VOC, as well as a wide spectrum of human and potentially zoonotic sarbecoviruses through inhibition of ACE2 binding to the RBD. | 21:55 |
| nixonix | Our data unveil a key antigenic site targeted by broadly-neutralizing antibodies and will guide the design of pan-sarbecovirus vaccines | 21:55 |
| de-facto | Interesting | 22:07 |
| de-facto | do you think next gen vaccines will contain synthetic antigens? | 22:08 |
| Brainstorm | New from ProPublica: Michigan Supreme Court Limits Use of Restraints on Juveniles: by Jodi S. Cohen ] ProPublica is a nonprofit newsroom that investigates abuses of power. Sign up for Dispatches , a newsletter that spotlights wrongdoing around the country, to receive our stories in your inbox every week. The Michigan Supreme Court on Wednesday [... want %more?] → https://is.gd/synsvi | 22:09 |
| de-facto | in such a way that they provoke antibodies to specific pre-selected epitopes only? | 22:09 |
| nixonix | yeah there are some vaccines using those, like ub-612 | 22:18 |
| nixonix | .title https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1.full | 22:20 |
| Brainstorm | nixonix: From www.biorxiv.org: A Novel SARS-CoV-2 Multitope Protein/Peptide Vaccine Candidate is Highly Immunogenic and Prevents Lung Infection in an Adeno Associated Virus Human Angiotensin-Converting Enzyme 2 (AAV hACE2) Mouse [...] | 22:21 |
| de-facto | yeah i remember having read about that one back then, i wonder if it would be possible to use their approach to induce B/T-cell responses against those highly conserved epitopes mentioned in the papers above | 22:24 |
| nixonix | probably. eg using two proteins, for mrna vaccine or whatever, one being s-protein or s1 for ab response, then another with selected epitopes like those in above papers | 22:30 |
| Brainstorm | Updates for Germany: +3140 cases (now 3.8 million) since 23 hours ago | 23:04 |
| nixonix | .title https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/coronaviruscovid19infectionsurveyantibodyandvaccinationdatafortheuk/21july2021 | 23:22 |
| Brainstorm | nixonix: From www.ons.gov.uk: Coronavirus (COVID-19) Infection Survey, antibody and vaccination data, UK - Office for National Statistics | 23:22 |
| Trippy72394 | I'm confused. What percentage of people who get the normal covid die? What percentage of people who get the delta variant die? | 23:24 |
| nixonix | while those are often inaccurate, they might have reached the herd immunity threshold. just funny that different regions all dropped at the same time | 23:24 |
| nixonix | IFR for unvaccinated depends, mostly on age | 23:25 |
| ublx | daily case numbers dropped rapidly after 'Freedom Day'. 'funny' indeed | 23:26 |
| ublx | ^in the UK | 23:26 |
| nixonix | if mostly young ppl get infected, for earlier variants IFR could be as low as 0.1-0.2%. then if its evenly spreaded, depends on median age and if the healthcare gets overhelmed by large number of infections. 0.5%-4% something, probably around 1% with in the western countries, maybe a bit more if really evenly spreaded, young and old | 23:29 |
| nixonix | without vaccines, that is | 23:29 |
| Trippy72394 | thank you | 23:30 |
| de-facto | IFR for the old variants (e.g. pre Alpha, Delta) is a perfect exponential of age | 23:30 |
| de-facto | in python one would write: def reciprocal_ifr(age): return int(round(186209 / 2**(age / 5.74485))) # https://dx.doi.org/10.1007%2Fs10654-020-00698-1 | 23:30 |
| Trippy72394 | much obliged | 23:30 |
| de-facto | according to meta analysis | 23:30 |
| de-facto | .title https://link.springer.com/article/10.1007/s10654-020-00698-1 | 23:30 |
| Brainstorm | de-facto: From link.springer.com: Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications | SpringerLink | 23:31 |
| Trippy72394 | checking... | 23:31 |
| nixonix | overWhelmed | 23:31 |
| de-facto | .ifr 85 | 23:31 |
| Brainstorm | de-facto, for every 7 infections at that age, one would progress to a fatal outcome, on average. | 23:31 |
| de-facto | with old variants, pre-vaccination | 23:31 |
| de-facto | so much changed by now | 23:31 |
| Trippy72394 | understood, thanks. | 23:32 |
| Trippy72394 | now, an "odds" question, if I may.... The odds that in 5 years we're out of the woods with no variant that wipes us all out? | 23:32 |
| Trippy72394 | The odds that in 5 years this is gone and we can all travel freely? | 23:33 |
| de-facto | it will not wipe us all out, thats very unlikely | 23:33 |
| Trippy72394 | ...or is this going to bounce around forever in pockets here and there... | 23:33 |
| de-facto | but if its still there in 5 years in some form? probably ... | 23:33 |
| Trippy72394 | not wipe us all out, okay, understood | 23:34 |
| Trippy72394 | still there in five years, probably, okay thanks | 23:34 |
| Trippy72394 | I also read that sinovac wears off. How true is this? | 23:34 |
| Trippy72394 | I got that vaccine. | 23:34 |
| nixonix | most of us have got it at least couple of times by then, prob more. vaccines should prevent getting to hospital for most, but how about different damages for brains, pancreatic b-cell islets, telomeres etc, how well does the vaccines prevent them, remains to be seen | 23:35 |
| de-facto | all the vaccines will wear off, but the immune system still knows the pathogen, its not naive anymore | 23:35 |
| Trippy72394 | I see. | 23:36 |
| Trippy72394 | Great channel. Thank you so much! | 23:36 |
| de-facto | nixonix, pancreatic b-cell islets? interesting, never heard of those yet | 23:36 |
| de-facto | .title https://www.nature.com/articles/s42255-021-00347-1 | 23:39 |
| Brainstorm | de-facto: From www.nature.com: SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas | Nature Metabolism | 23:39 |
| nixonix | *beta cells | 23:39 |
| de-facto | .title https://www.nature.com/articles/s41467-021-23886-3 | 23:39 |
| Brainstorm | de-facto: From www.nature.com: Viral infiltration of pancreatic islets in patients with COVID-19 | Nature Communications | 23:39 |
| Brainstorm | Updates for Turkey: +22291 cases (now 5.7 million), +76 deaths (now 51124) since 20 hours ago | 23:41 |
| nixonix | couple of nasal vaccine articles i pasted another day: | 23:43 |
| nixonix | .title https://www.scientificamerican.com/article/to-beat-covid-we-may-need-a-good-shot-in-the-nose/ | 23:43 |
| Brainstorm | nixonix: From www.scientificamerican.com: To Beat COVID, We May Need a Good Shot in the Nose - Scientific American | 23:43 |
| nixonix | .title https://science.sciencemag.org/content/373/6553/397 | 23:44 |
| Brainstorm | nixonix: From science.sciencemag.org: Scent of a vaccine | Science | 23:44 |
| nixonix | when these vaccines seem to leak bad with this variant, maybe we need those. especially if those different damages happen with breakthrough infections | 23:45 |
| de-facto | i wonder when we will have stats about long-COVID for breakthrough compared to naive infections | 23:46 |
| de-facto | there were some polls on facebook, but i suspect heavily biased https://www.medrxiv.org/content/10.1101/2021.07.23.21261030v1 | 23:47 |
| nixonix | different types of long covid. those in media usually are only about symptoms continuing. then if they finally go away, you are cured | 23:47 |
| nixonix | but how about life long damage, some of which you are not aware of.. | 23:47 |
| nixonix | its like clinical based definitions of a disease. if you have symptoms, you have a disease. a case | 23:48 |
| de-facto | i guess we simply dont know yet how long lasting etc | 23:49 |
| nixonix | permanent damages im worried about | 23:49 |
| de-facto | there were some efforts to develop tests for something similar before https://www.pnas.org/content/116/21/10250 | 23:50 |
| de-facto | also they got funding for investigating the possibility of a blood test | 23:50 |
| de-facto | .title https://www.cam.ac.uk/research/news/biological-fingerprints-of-long-covid-in-blood-could-lead-to-diagnostic-test-say-cambridge | 23:50 |
| Brainstorm | de-facto: From www.cam.ac.uk: Biological ‘fingerprints’ of long COVID in blood could lead to diagnostic test, say Cambridge scientists | University of Cambridge | 23:50 |
| nixonix | i just saw some new biomarker product mentioned. finnish news, but ill look for english article or something | 23:51 |
| Brainstorm | New from NPR: The Pentagon Will Require Masks To Be Worn Indoors Even By Those Who Are Vaccinated: Reversing a decision made in May that allowed fully vaccinated people to ditch the mask, the Department of Defense will follow the CDC's most recent mask guidance. → https://is.gd/YEIuSY | 23:52 |
| nixonix | last summer i linked a few upcoming biomarker products or softwares here, but its taken awhile until they have come for use in real world | 23:52 |
| nixonix | its this one. a bit older, but it has information that new articles have not. only 3 biomarkers though, CRP, some TNF and interferon gamma related markers | 23:59 |
| nixonix | .title https://www.360dx.com/immunoassays/memed-developing-inflammatory-biomarker-tests-use-guiding-covid-19-treatment | 23:59 |
| Brainstorm | nixonix: From www.360dx.com: | 360Dx | 23:59 |
Generated by irclog2html.py 2.17.0 by Marius Gedminas - find it at https://mg.pov.lt/irclog2html/!