libera/##covid-19/ Wednesday, 2022-12-28

BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): This does not mean we know all about IgG4: it does change cellular interactions and activation of the complement system. But the data is clear from many other studies: increased neutralisation activity and infection and disease protection from repeated [... want %more?] → https://twitter.com/Marc_Veld/status/160787678714017382900:22
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): And for those not having understood the Tetanus part: that vaccine is not against the bacteria, but relies entirely on neutralising antibodies against the toxin. You get 5 in your early years, and yes, they work and safe you from a horrible death. → https://twitter.com/Marc_Veld/status/160789471890990694401:30
BrainstormUpdates for Norway: +285 cases since 23 hours ago02:03
BrainstormNew from r/Science: science: More obesity in three- and four-year-olds during COVID-19 pandemic: Study found obesity in 3-year-old girls increased from 2.8% to 3.9%. Four-year-olds increased in obesity, and overweight (girls) and the prevalence of underweight decreased in boys. → https://old.reddit.com/r/science/comments/zwvnma/more_obesity_in_three_and_fouryearolds_during/03:16
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: India Begins Testing Visitors for COVID-19 – NBC 7 San Diego → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/zwy7sa/india_begins_testing_visitors_for_covid19_nbc_7/03:54
BrainstormUpdates for New Zealand: +31994 cases since 18 hours ago — North Macedonia: +201 cases, +6 deaths since 6 days ago — Uganda: +175 cases since 22 days ago — Pakistan: +26 cases since 23 hours ago04:08
BrainstormNew from This Week In Virology: TWiV 969: Carl Zimmer on COVID-19: Carl Zimmer visits the Incubator to record a wide-ranging conversation about COVID-19, including origins, vaccines, public health responses, and impact on society. → https://www.microbe.tv/twiv/twiv-969/06:11
BrainstormUpdates for Germany: +60452 cases, +204 deaths since a day ago — Tokyo, Japan: +22062 cases, +22 deaths since 23 hours ago — North Rhine-Westphalia, Germany: +17918 cases, +40 deaths since 23 hours ago — Aichi, Japan: +15469 cases, +2 deaths since 23 hours ago07:02
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: An estimated 19 million US adults living with long-COVID → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/zx2sok/an_estimated_19_million_us_adults_living_with/07:48
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: History of COVID-19 increases risk of fatigue and other long COVID symptoms in adults and children: include fatigue, cognitive impairment, diabetes, shortness of breath, mental health conditions, cardiovascular [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/zx2tpk/history_of_covid19_increases_risk_of_fatigue_and/07:58
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: With long COVID clinic set to close, patients worry about access | MaineHealth is set to close its long COVID clinic in January, saying patients will be better served by their primary care doctors. → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/zx3119/with_long_covid_clinic_set_to_close_patients/08:07
BrainstormNew from COVID on Twitter: Tulio de Oliveira (@Tuliodna): UK wildlife ‘devastated by litany of weather extremes’ in 2022. Unfortunately this is a time bomb for fueling new epidemics and pandemics as many species of animals are affected by extreme weather events. theguardian.com/environment/20… → https://twitter.com/Tuliodna/status/160800602456419532908:55
BrainstormNew from r/Coronavirus: Daily Discussion Thread | December 28, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/zx3zlx/daily_discussion_thread_december_28_2022/09:05
BrainstormUpdates for Taiwan: +28158 cases, +25 deaths, +34941 tests since a day ago09:07
BrainstormUpdates for Japan: +194077 cases, +407 deaths since 23 hours ago — Lithuania: +691 cases, +1 deaths since 23 hours ago — Delhi, India: +16 cases since a day ago — Bihar, India: +12 cases since a day ago10:09
BrainstormNew from r/Science: science: BioNTech Delivers First Patient Dose In Herpes Vaccine Clinical Trial → https://old.reddit.com/r/science/comments/zx4fpe/biontech_delivers_first_patient_dose_in_herpes/10:33
BrainstormUpdates for Russia: +6202 cases, +56 deaths since a day ago11:11
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Another example showing that however important observations and papers are to understand COVID-19, for non-experts they are just details. The context and meaning or bigger picture is best left to experts who have the knowledge to do so. Otherwise it goes [... want %more?] → https://twitter.com/Marc_Veld/status/160804043305725132811:12
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): The sad thing is that public health, which could have been a real winner from a pandemic, is severely undermined. Enormous mistrust in science and medicine, lots of quackery, much lower uptake of vaccines and the return of old infectious diseases are not to be celebrated. → https://twitter.com/Marc_Veld/status/160804938473796403211:42
BrainstormUpdates for Slovenia: +2350 cases since 23 hours ago12:01
BrainstormNew from BioNTech: BioNTech to Present at the 41st Annual J.P. Morgan Healthcare Conference: Mainz, Germany, December 28, 2022 (GLOBE NEWSWIRE) – BioNTech SE (Nasdaq: BNTX, “BioNTech” or “the Company”) announced today that CEO and [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/biontech-present-41st-annual-jp-morgan-healthcare-conference12:51
BrainstormUpdates for Hong Kong: +20865 cases, +59 deaths since a day ago — China: +20865 cases, +59 deaths since a day ago — Poland: +803 cases, +6 deaths since a day ago13:03
BrainstormNew from Reddit (test): nCoV: Global COVID Cases For 28DEC22 → https://old.reddit.com/r/nCoV/comments/zx7zdy/global_covid_cases_for_28dec22/13:11
BrainstormNew from Reddit (test): nCoV: China to issue tourist passports in huge move away from COVID restrictions - as Hong Kong scraps quarantine rule | 28DEC22 → https://old.reddit.com/r/nCoV/comments/zx8pct/china_to_issue_tourist_passports_in_huge_move/13:51
BrainstormNew from Reddit (test): nCoV: Doctors describe chaos in hospitals as COVID sweeps across China | Video runtime 2:40 | 28DEC22 ; → https://old.reddit.com/r/nCoV/comments/zx8uqb/doctors_describe_chaos_in_hospitals_as_covid/14:01
BrainstormNew from Reddit (test): nCoV: Germany's governing coalition argues over COVID restrictions | 28DEC22 → https://old.reddit.com/r/nCoV/comments/zx9e2s/germanys_governing_coalition_argues_over_covid/14:21
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Once more ..... scientific findings need context (by experts). This is a very good thread pointing out the context of IgG4 during vaccination and infection, what it means, and especially what it does not! twitter.com/SabiVM/status/… → https://twitter.com/Marc_Veld/status/160809382460509389014:40
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): How terribly sad this needs pointing out, but unfortunately it does. No vaccines do not cause cancer, a multistep process, they can reduce risk to cancer caused by infections. twitter.com/gorskon/status… → https://twitter.com/Marc_Veld/status/160809671629249740814:50
BrainstormUpdates for Bangladesh: +21 cases, +2666 tests since a day ago15:08
LjL-Matrixde-facto: first two flights from China to Italy, 50% positive15:34
LjL-MatrixBut the PCRs weren't mandatory anyway so not everyone was tested15:34
de-factonice who knows what variants they breed with such a massive incidence there15:35
LjL-MatrixAnd as usual... What about the other 50%? Of course they're allowed to go on for their business. But I think it's pretty obvious what will happen to most of them in the next couple of days15:35
de-factopossibly but not necessarily circumventing the type of immunity most prevalent in western countries15:35
LjL-MatrixThe EU "is thinking" about making PCR mandatory for all of them. I'm sure they will be timely as usual15:35
de-factowhy dont we demand them to quarantine just like they did in China? it seemed to work15:36
de-factothere is a faint hope that the variants able to spread in China will not be able to evade BA.5 type of immunity (as such is not a major selection factor in China i guess), yet if the parental variants are BQ.1 or XBB that could also not be the case15:38
BrainstormNew from r/Coronavirus: Coronavirus: China’s elite give Paxlovid to friends as demand soars for Covid drug → https://old.reddit.com/r/Coronavirus/comments/zxaaym/chinas_elite_give_paxlovid_to_friends_as_demand/15:49
BrainstormUpdates for Austria: +4711 cases, +31 deaths, +150282 tests since 14 hours ago — Singapore: +1547 cases since a day ago — Iran: +60 cases since a day ago16:10
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Study finds differences in biomarkers in #longCovidUsing conventional statistics + state-of-the-art machine learning, two vascular transformation biomarkers were identified distinguishing LC patients from acutely ill C19 inpatients +healthy controls [... want %more?] → https://twitter.com/GANyborg/status/160811630037458944116:10
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): There are ~7 million Americans who are immunocompromised, more vulnerable to severe Covid, and now Evusheld rendered ineffective. We've just launched a new direct-to-participant-research program with free molecular tests & rapid delivery of meds if [... want %more?] → https://twitter.com/EricTopol/status/160812902079699763316:59
BrainstormUpdates for Kosovo: +6 cases since a day ago17:00
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent BoosterYes the bivalent boosters work well, good neutralising antibodies against new variants.nejm.org/doi/full/10.10… → https://twitter.com/Marc_Veld/status/160813752119971840217:38
BrainstormUpdates for Chile: +5622 cases, +5 deaths, +24265 tests since a day ago — Sri Lanka: +16 cases, +2 deaths since a day ago18:02
BrainstormNew from COVID on Twitter: Edward Nirenberg    (@ENirenberg): - high levels of antibody sialylation (which mRNA vaccines do exceptionally well) associates with mild disease (IMO not enough on this in the review, see- science.org/doi/10.1126/sc…)- high levels of afucosylated antibodies associates with severe [... want %more?] → https://twitter.com/ENirenberg/status/160814507495254016318:08
BrainstormNew from Politico: Italy mandates COVID tests for travelers from China: Beijing has lifted its zero-COVID policies, which included months-long lockdowns. → https://www.politico.eu/article/italy-mandates-covid-tests-for-travelers-from-china/18:18
BrainstormNew from WebMD: Is Long COVID Less Likely With Omicron Strains?: Whether it's an effect of vaccination, immunity from previous infections, or perhaps evolution, doctors are beginning to hope the Omicron variant of the coronavirus might be milder. They're also hoping it may be less likely to [... want %more?] → https://www.webmd.com/covid/news/20221228/is-long-covid-less-likely-omicron-strains18:57
BrainstormUpdates for Montenegro: +38 cases since 21 hours ago19:04
BrainstormNew from Science Daily: Alveolar macrophages help CD8+ T cells go (anti-)viral: Researchers have found that antigen-specific killer T cells (CD8+ T cells) rapidly expand in the lungs when primed by antigen-presenting lung-resident alveolar macrophages (AMs). This interaction helps protect against viral [... want %more?] → https://www.sciencedaily.com/releases/2022/12/221228130409.htm19:37
BrainstormNew from COVID on Twitter: (translated) Penguinone (@penguinone): SARS-CoV-2 Infection, Hospitalization, and Death in Vaccinated and Infected Individuals by Age GroupsSARS-CoV-2 Infection, Hospitalization, and Death in Vaccinated and Infected Individuals by Age Group in Indiana, [... want %more?] → https://twitter.com/penguinone/status/160817368239594291219:56
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Back to the study in the original post: Since Covid-19 is partly a microvascular and thrombotic disease, it is logical that vascular transformation blood biomarkers may be useful to diagnose LC. The study finds vasculature transformation is active in LC 1-6 [... want %more?] → https://twitter.com/GANyborg/status/160818104422570803220:26
BrainstormUpdates for Canada: +16 deaths since 21 hours ago21:09
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Italy following up with mandatory testing, after app. 50% of passengers from China had COVID-19.To whom it may concern: These sorts of decisions should not be delayed.twitter.com/tracyalloway/s… → https://twitter.com/GANyborg/status/160819660596599603221:25
BrainstormNew from Politico: US to require COVID tests for travelers coming from China: The Biden administration announced Wednesday that it will require anyone arriving by air from China to provide a negative COVID test, following a surge of COVID-19 cases across China as [... want %more?] → https://www.politico.com/news/2022/12/28/u-s-to-require-covid-tests-for-travelers-coming-from-china-0007569321:35
BrainstormNew from StatNews: U.S. imposes Covid testing requirements on travelers from China: The U.S. announced Wednesday that it is requiring travelers from China to show a negative Covid-19 test before boarding flights to the U.S. → https://www.statnews.com/2022/12/28/u-s-imposes-covid-testing-requirements-on-travelers-from-china/21:45
BrainstormUpdates for France: +26081 cases, +140 deaths since a day ago22:11
BrainstormNew from StatNews: STAT+: Drug companies set sights on new Covid medicines to boost depleted arsenal: New variants, as well as the loss of two treatments for immunocompromised people, makes it more urgent to develop a new generation of medicines. → https://www.statnews.com/2022/12/28/drug-companies-set-sights-on-new-covid-medicines-to-boost-depleted-arsenal/22:25
de-facto%title https://apnews.com/article/health-china-covid-19-pandemic-ab51ca49e69633ae7028db36d06c54f322:29
Brainstormde-facto: From apnews.com: US will require COVID-19 testing for travelers from China | AP News22:29
de-factoLjL,  ^ ^22:29
LjL-MatrixEurope is figuring it out too22:30
LjL-MatrixLet's just hope we don't take too long22:30
de-factosequencing fresh samples of the new variant breeding efforts could indicate progress by antigenic drift rates22:34
de-factoalso it could allow to test against neutralization with blood containing the most prevalent type of immunity in USA and EU22:35
de-factoimho sequencing every positive sample of travelers from CHina should be mandatory as well as quarantine22:35
de-facto%title https://erictopol.substack.com/p/a-new-variant-alert22:57
Brainstormde-facto: From erictopol.substack.com: A new variant alert - by Eric Topol - Ground Truths22:57
BrainstormUpdates for Ethiopia: +187 cases since a day ago23:01
BrainstormNew from NPR Science: How a scrappy African start-up could forever change the world of vaccines: Afrigen aims to use mRNA technology not only to teach low-resource countries to make their own COVID vaccines but to attack other killer [... want %more?] → https://www.npr.org/sections/goatsandsoda/2022/12/28/1145836719/how-a-scrappy-african-start-up-could-forever-change-the-world-of-vaccines23:13
BrainstormNew from ##covid-19 Zotero group: A new variant alert: Type Blog Post Author Eric Topol URL https://erictopol.substack.com/p/a-new-variant-alert Date 2022-12-23 Accessed 2022-12-28 22:29:43 Website Type Substack newsletter Abstract The XBB.1.5 variant is on a growth spurt in the United States Blog Title Ground Truths → https://www.zotero.org/groups/covid_links/items/374UYSPF23:33
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): New @NEJM A randomized trial of an oral remdesivir analog drug (VV116) vs Paxlovid suggests it may provide an alternative (fulfilling the pre-specified non-inferiority criteria, but 1.17 hazard ratio)nejm.org/doi/full/10.10… pic.twitter.com/TmvZTCWDMe → https://twitter.com/EricTopol/status/160823199576267571223:54

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