| Brainstorm | New from The Atlantic: COVID Vaccines Are Turning Into Flu Shots: For all the legwork that public-health experts have done over the past few years to quash comparisons between COVID-19 and the flu , there sure seems to be a lot of effort nowadays to equate the [... want %more?] → https://www.theatlantic.com/health/archive/2023/01/annual-seasonal-covid-vaccine-shots-federal-regulation/672854/ | 00:18 |
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| LjL | de-facto, https://www.biorxiv.org/content/10.1101/2023.01.25.525485v1 one more paper showing mucosal immunity wouldn't be such a bad thing | 00:31 |
| de-facto | yes indeed it makes sense to vaccinate in a way that targets the same tissue as the pathogen itself when initial replication in the hosts body is the earliest opportunity to ramp up immune defensive reactions: the respiratory system | 00:35 |
| de-facto | i honestly dont understand why not more efforts are invested into developing respiratory vaccines, e.g. a replication competent yet codon de-optimized SARS-CoV-2 strain such as basic research already was done for | 00:36 |
| de-facto | probably the assumption is that by now everybody gets it anyway, the costs are lots of long lasting COVID problems in the population | 00:36 |
| LjL | what an asinine premise here https://www.theatlantic.com/health/archive/2023/01/annual-seasonal-covid-vaccine-shots-federal-regulation/672854/ | 00:41 |
| LjL | just because COVID shots are "becoming similar in pace to flu shots", then COVID is actually comparable to the flu after all | 00:41 |
| LjL | uh... no? | 00:41 |
| Tuvix | I still refer back to published data on death (which is easier to track than complex issues like long-COVID.) The US data is pretty ugly here, but it's been unfashionable for some time to point out the continued deaths. | 01:08 |
| Tuvix | Other countries with well-reported dealths for both categories could be compared too, but I just know where the US data is more readily. Using the past-season of influenza, the average going back 10 years is 34.7k annually, focused around the winter flu season. That number represented in "deaths per 100k per week" (divide by a population estimate of 3310 (units of 100k people)) and divide further by 52 | 01:10 |
| Tuvix | weeks in a year gives ~0.20 influenza deaths per 100k per (averaged) week. Source: https://www.cdc.gov/flu/about/burden/past-seasons.html | 01:11 |
| Tuvix | Next, compare the US COVID deaths over time on this chart, realizing that *any* time the yellow line is above 0.20, we're doing "worse than the flu." (a line at 0.2 would mean we have "another influenza" worth of death that week of reporting.) | 01:12 |
| Tuvix | https://covid.cdc.gov/covid-data-tracker/#trends_weeklycases_7daydeathsper100k_00 | 01:12 |
| Brainstorm | New from WebMD: FDA Panel Backs Shift Toward One-Dose COVID Shot: The FDA’s vaccine advisers lent support to the agency’s plan to try to simplify future COVID shots, with an aim of having many people get just one uniform dose in the fall. → https://www.webmd.com/vaccines/covid-19-vaccine/news/20230126/fda-panel-backs-shift-toward-one-dose-covid-shot | 01:16 |
| Tuvix | This past week, COVID has taken the lives of roughly 6 times that of annual flu deaths (converting both to units of death-per-average-week.) If we're comparing COVID to flu, we need to be honest and say that it's (currently) 6 flus (7 if you also add in the "traditional influenza") | 01:16 |
| Tuvix | By comparison, we'd be irate if a car manufacturer suddenly changed crash protection and that year's model killed 6 times as many people per rate of crashes experienced by their drivers. But it's "just fine" for COVID. There are implications globally for accountability, yet it hasn't resulted in action. | 01:20 |
| Tuvix | Another (US-centric) comparison: some may say it's bad form to use the current relative COVID death spike, so let's instead use the last 12-months: in the same units of death/100k/week that the 0.20 influenza used, COVID cost the lives of 1.38. That's 7-times worse. Being honest in calculations matters, so using annually-averaged units is crucial. | 01:25 |
| Brainstorm | Updates for Canada: +913 cases, +73 deaths since 5 hours ago | 02:09 |
| Brainstorm | Updates for Norway: +53 cases, +76 deaths since a day ago | 02:59 |
| Brainstorm | New from r/Coronavirus: Coronavirus: FDA advisers recommend updating Covid vaccines → https://old.reddit.com/r/Coronavirus/comments/10m8cf3/fda_advisers_recommend_updating_covid_vaccines/ | 03:49 |
| Brainstorm | Updates for Germany: +13155 cases, +175 deaths since a day ago | 06:00 |
| Brainstorm | New from r/Coronavirus: Coronavirus: With rise of new coronavirus variants, FDA halts authorization of Evusheld | CNN → https://old.reddit.com/r/Coronavirus/comments/10mafxk/with_rise_of_new_coronavirus_variants_fda_halts/ | 06:30 |
| Brainstorm | Updates for Minnesota, United States: +5341 cases, +78 deaths since 6 days ago — Moscow, Russia: +2411 cases, +10 deaths since 23 hours ago — Dalarna, Sweden: +1524 cases, +15 deaths since 6 days ago — Saint Petersburg, Russia: +704 cases, +11 deaths since 23 hours ago | 07:02 |
| Brainstorm | Updates for Taiwan: +24348 cases, +15 deaths since 23 hours ago | 09:00 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | January 27, 2023: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/10mfl23/daily_discussion_thread_january_27_2023/ | 09:10 |
| Brainstorm | New from Science-Based Medicine: Should We Accept Unvaccinated Children Dying of COVID as a “Matter of Course”?: The same doctors who scold us for potentially minimizing "slightest bit of inflammation in the heart" when the vaccine is to blame, shame us for trying [... want %more?] → https://sciencebasedmedicine.org/should-we-let-unvaccinated-children-die-of-covid-as-a-matter-of-course/ | 09:29 |
| Brainstorm | Updates for Delhi, India: +8 cases since a day ago — West Bengal, India: +6 cases since a day ago | 10:03 |
| Brainstorm | New from r/COVID19: COVID19: A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients → https://old.reddit.com/r/COVID19/comments/10mh0wf/a_sexbiased_imbalance_between_tfr_tph_and/ | 10:45 |
| Brainstorm | Updates for Russia: +7164 cases, +41 deaths since 23 hours ago | 10:59 |
| Brainstorm | New from EMA: What's new: General: Procedural advice for vaccine platform technology master file (vPTMF) certification - Scientific guideline → https://www.ema.europa.eu/en/procedural-advice-vaccine-platform-technology-master-file-vptmf-certification-scientific-guideline | 11:33 |
| Brainstorm | New from EMA: What's new: Document: Guideline on clinical evaluation of vaccines - Revision 1 → https://www.ema.europa.eu/documents/scientific-guideline/guideline-clinical-evaluation-vaccines-revision-1_en.pdf | 11:52 |
| Brainstorm | New from r/COVID19: COVID19: Effects of a booster dose of BNT162b2 on spike-binding antibodies to SARS-CoV-2 Omicron BA.2, BA.3, BA.4 and BA.5 subvariants in infection-naïve and previously-infected individuals → https://old.reddit.com/r/COVID19/comments/10mi3pi/effects_of_a_booster_dose_of_bnt162b2_on/ | 12:02 |
| Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 27JAN23 → https://old.reddit.com/r/nCoV/comments/10miakb/global_covid_cases_for_27jan23/ | 12:11 |
| Brainstorm | New from Reddit (test): nCoV: Judge questions clarity of new California law targeting doctors who share COVID-19 misinformation | 25JAN23 → https://old.reddit.com/r/nCoV/comments/10mitl9/judge_questions_clarity_of_new_california_law/ | 12:50 |
| Brainstorm | New from r/COVID19: COVID19: Altered host protease determinants for SARS-CoV-2 Omicron → https://old.reddit.com/r/COVID19/comments/10mjbz3/altered_host_protease_determinants_for_sarscov2/ | 13:19 |
| Brainstorm | New from Reddit (test): CoronavirusUK: Coronavirus (COVID-19) Infection Survey, UK: 27 January 2023 → https://old.reddit.com/r/CoronavirusUK/comments/10ml1n9/coronavirus_covid19_infection_survey_uk_27/ | 14:45 |
| Brainstorm | New from Contagion Live: FDA Withdraws EUA for Evusheld: The federal agency does not want clinicians utilizing this neutralizing antibody as newer, circulating COVID-19 strains and efficacy against them is limited. → https://www.onclive.com/view/fda-withdraws-eua-for-evusheld | 14:55 |
| Brainstorm | Updates for Nepal: +6 cases since 23 hours ago | 15:02 |
| Brainstorm | New from r/COVID19: COVID19: Collateral damage from debunking mRNA vaccine misinformation → https://old.reddit.com/r/COVID19/comments/10mlebo/collateral_damage_from_debunking_mrna_vaccine/ | 15:05 |
| Brainstorm | New from ProPublica: Judge Orders Washington State Private Special Education School to Turn Over Records: by Lulu Ramadan , The Seattle Times This article was produced for ProPublica’s Local Reporting Network in partnership with The Seattle Times. Sign up for Dispatches to get stories like this one [... want %more?] → https://www.propublica.org/article/northwest-soil-schools-public-records | 15:14 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Some Republicans push to probe Pfizer over Covid-19 ‘mutations’; Warren urges FTC to probe pharma mergers → https://www.statnews.com/pharmalot/2023/01/27/covid19-vaccines-pfizer-biontech-astrazeneca-jnj-warren-mergers-amgen/ | 15:34 |
| Brainstorm | New from Reddit (test): nCoV: Change to Covid vaccine formulation signals start of FDA pivot in immunization strategy | 27JAN23 → https://old.reddit.com/r/nCoV/comments/10mmcqe/change_to_covid_vaccine_formulation_signals_start/ | 15:54 |
| Brainstorm | Updates for Austria: +3155 cases, +9 deaths since 13 hours ago | 16:04 |
| Brainstorm | New from ClinicalTrials.gov: (news): Comparison of Home- vs. Gym-based Exercise Delivery Modes → https://clinicaltrials.gov/ct2/show/NCT05701943 | 17:02 |
| Brainstorm | Updates for Italy: +38159 cases, +345 deaths since 7 days ago — Spain: +8801 cases, +248 deaths since 6 days ago | 17:06 |
| Brainstorm | New from ClinicalTrials.gov: (news): Comparison of Home- vs. Gym-based Exercise Delivery Modes → https://clinicaltrials.gov/ct2/show/NCT05701943 | 17:50 |
| Brainstorm | New from ClinicalTrials.gov: (news): Efficacy and Safety of Jaktinib in Patients With Severe Novel Noronavirus Pneumonia → https://clinicaltrials.gov/ct2/show/NCT05702788 | 18:09 |
| Brainstorm | New from ClinicalTrials.gov: (news): COVID-19 Self-testing Study → https://clinicaltrials.gov/ct2/show/NCT05701878 | 18:19 |
| Brainstorm | New from Contagion Live: To Meet Updated FDA Recommendations, Novavax Will Update Protein-Based COVID-19 Vaccine: Novavax will update its protein-based COVID-19 vaccine, but maintains the current vaccine is effective against current and future variants. → https://www.onclive.com/view/to-meet-updated-fda-recommendations-novavax-will-update-protein-based-covid-19-vaccine | 19:17 |
| Brainstorm | Updates for Canada: +76 deaths since 22 hours ago | 20:00 |
| Brainstorm | New from Reddit (test): nCoV: China’s most scenic destinations packed with tourists despite covid risks | 27JAN23 → https://old.reddit.com/r/nCoV/comments/10mugcp/chinas_most_scenic_destinations_packed_with/ | 21:04 |
| Brainstorm | New from StatNews: STAT+: Pfizer is scolded by a U.K. trade group for remarks its CEO made about vaccination: A U.K. pharmaceutical industry trade group ruled on a complaint that Pfizer CEO Albert Bourla's remarks to the BBC were “extremely promotional in nature.” → https://www.statnews.com/pharmalot/2023/01/27/pfizer-covid19-vaccines-uk-bourla-children/ | 21:33 |
| -Bridgestorm- 🌒 Linog! Lindol! Earthquake! 5.4 Mb tremor, registered by EMSC,KOERI,alomax, with 54 reports, 7 early, occurred 17 minutes ago (20:25:31 UTC), during a crescent moon night, Sulangan, Philippines (10.72, 125.57) ± 10 km likely felt 300 km away by 100 people (www.seismicportal.eu) | 21:42 | |
| Brainstorm | New from Contagion Live: The Top 5 COVID-19 Stories This Week: The week's most-clicked COVID-19 stories included vaccine updates, new variants, and a pivotal FDA advisory committee vote. → https://www.onclive.com/view/the-top-covid-19-news-this-week | 22:11 |
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