| Brainstorm | Updates for Cuba: +18 cases since a day ago | 00:09 |
|---|---|---|
| Brainstorm | New from r/COVID19: COVID19: Detection of viable SARS-CoV-2 in retrospective analysis of aerosol samples collected from hospital rooms of patients with COVID-19 → https://old.reddit.com/r/COVID19/comments/1231kxx/detection_of_viable_sarscov2_in_retrospective/ | 00:14 |
| Autowired | no it was only a standard flu | 00:20 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Covid-19 Staff Testing and Outcomes in Nursing Homes: In this large study in skilled nursing facilities, greater surveillance testing for Covid-19 among staff was associated with clinically meaningful reductions in [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/1231udo/covid19_staff_testing_and_outcomes_in_nursing/ | 00:24 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Early treatments were very much tried, with dexamethasone, a cheap steroid very successful in preventing immune damage. Funds and time were wasted on IVM, bc of much pseudoscience and quackery.nejm.org/doi/full/10.10… → https://twitter.com/Marc_Veld/status/1640121394900901889 | 00:43 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): And yes, vaccines are very safe, as we know from 100Ms of vaccinations tested, and billions given. This is the reason that virologists, immunologists and epidemiologists were needed, not this cardiologist.thelancet.com/journals/lanin… → https://twitter.com/Marc_Veld/status/1640121398134730759 | 00:52 |
| ferret | de-facto: today is my 7th and final day of paxlovid | 02:04 |
| ferret | LOL | 02:04 |
| ferret | i cant beleve i commited to 7 days lets see what happens | 02:04 |
| ferret | i could do 8 but i donno if it will bennifit | 02:05 |
| de-facto | nice how are you doing? | 02:06 |
| ferret | de-facto: not bad at all feel great. coughing up more fluid | 02:06 |
| ferret | lol | 02:07 |
| de-facto | sounds like fun :P | 02:07 |
| de-facto | but at least whats out isnt there anymore | 02:07 |
| ferret | prob coughing up lots of dead virus | 02:07 |
| de-facto | yeah and cells | 02:07 |
| de-facto | clearing the battlefield | 02:07 |
| ferret | ahahahahahhaa | 02:07 |
| ferret | de-facto: 8 days would be overkill right? | 02:08 |
| de-facto | what did your MD say, how long shoudl you take Paxlovid? | 02:08 |
| ferret | for the omicron | 02:08 |
| de-facto | i have no idea, i never took it | 02:08 |
| ferret | said i could take it up to 10 days | 02:08 |
| ferret | depends on how i feel i guess | 02:08 |
| ferret | 5 to 10 days max and if i want i could go for 15 | 02:09 |
| ferret | but that would be super overkill | 02:09 |
| ferret | lol | 02:09 |
| de-facto | Paxlovid, like other meds, comes with unwanted side effects as well as its main target effect (suppression of viral replication), hence the balance must be considered as benefit to risk ratio | 02:09 |
| ferret | yea 7 days is like 10 fold of a regular 5 days dose right | 02:10 |
| ferret | for omicron anyways | 02:10 |
| de-facto | Id assume it depends on when your own immune system got the new generation of antibodies ready and released into your system to take over with its own suppression effect on the viral replication, just so that the cellular reproduction number stays below 1 | 02:10 |
| de-facto | e.g. for each virus existing less than one virus should be reproduced in order to ensure that the virus population is starving out | 02:11 |
| de-facto | right now its a combination of Paxlovid and your immune system that suppresses the viral replication | 02:11 |
| ferret | nice | 02:12 |
| de-facto | but as soon as your immune system got the new generation of antibodies and other mechanisms specifically for this variant of the virus ready to ensure this sufficient suppression of viral replication it does not need the help from Paxlovid anymore | 02:12 |
| ferret | de-facto: thats a good point | 02:13 |
| ferret | ill stop paxlovid today. for the record will be 7 days | 02:13 |
| ferret | de-facto: i did notice something | 02:14 |
| de-facto | at the very first variants and without vaccination there were some challenge trials made to explore the viral load etc | 02:14 |
| de-facto | %title https://www.nature.com/articles/s41591-022-01780-9 | 02:14 |
| Brainstorm | de-facto: From www.nature.com: Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults | Nature Medicine | 02:14 |
| ferret | de-facto: my creatine levels were elivated | 02:15 |
| ferret | im at 1.34 mg/dL | 02:15 |
| de-facto | %title https://www.nature.com/articles/s41591-022-01780-9/figures/2 | 02:15 |
| Brainstorm | de-facto: From www.nature.com: Fig. 2: Viral shedding after a short incubation period peaks rapidly after human SARS-CoV-2 challenge. | Nature Medicine | 02:15 |
| de-facto | look at the infectious viral load by culture over days after contamination (the red curves) | 02:16 |
| de-facto | it seems after 7-8 days the viral load goes down, hence the immune system seems to be able to attenuate viral reproduction below 1 but that is without antiviral meds, hence the immune reaction may be more intense because of the higher viral load | 02:17 |
| de-facto | also its another variant (one of the very early variants) as well as for non-vaccinated naive immune systems afaik | 02:17 |
| ferret | de-facto: wow | 02:18 |
| ferret | this is amazing | 02:18 |
| ferret | de-facto: i wonder if re infection of the virus is more possible because of the use of antivirals | 02:20 |
| ferret | because my immune system had help stop replication of the virus | 02:20 |
| ferret | this is interesting | 02:20 |
| de-facto | i do not know that, but i think that e.g. vaccination also is less exposure of antigen to the immune system and still works | 02:22 |
| de-facto | but indeed thats an interesting question | 02:23 |
| ferret | were basicly supressing the immune response | 02:24 |
| de-facto | not really | 02:25 |
| de-facto | its suppressing a key mechanism in the viral replication (as an antiviral) | 02:25 |
| ferret | de-facto: the entire time except for day 0 i had no fever no chills because of the antiviral | 02:27 |
| ferret | it was aamzing | 02:27 |
| ferret | lol | 02:27 |
| ferret | going to be honest made covid feel like nothing | 02:27 |
| de-facto | https://en.wikipedia.org/wiki/Nirmatrelvir/ritonavir#Pharmacodynamics | 02:27 |
| ferret | de-facto: | 02:36 |
| de-facto | ye | 02:37 |
| ferret | remember the old ritonavir on NDC 0069-1085-30 | 02:37 |
| ferret | has the little syboml on it | 02:37 |
| ferret | the manufacture it discontunied there ritonavir when they moved to NDC 0069-0345-30 | 02:37 |
| ferret | i noticed the discontinued ritonavir had more strange tastes then the new manufacture | 02:38 |
| ferret | lol | 02:38 |
| ferret | tested both | 02:38 |
| LjL | i'm not sure de-facto remembers the symbols on Ritonavir :P | 02:42 |
| ferret | lol | 02:42 |
| ferret | the symbol looks cool | 02:42 |
| LjL | <ferret> yea 7 days is like 10 fold of a regular 5 days dose right ← err, how so? O.o | 02:43 |
| de-facto | have never seen any of those meds in RL | 02:44 |
| ferret | well it depends on when the person starts the anti viruals right if its on day 0 vs day 4 | 02:44 |
| ferret | and how much of the viral load is down by day 4, day 0 being start of symtoms | 02:45 |
| ferret | and the strain of covid | 02:45 |
| de-facto | yes it depends on many factors | 02:46 |
| LjL | i don't see hwo you get to that 10x factor though... | 02:46 |
| ferret | ill have to ask my doctor again its just something they said | 02:47 |
| ferret | for preventing rebound | 02:47 |
| ferret | they came up with that factor lol | 02:47 |
| ferret | there is a higher dose pack of paxlovid | 02:48 |
| ferret | but its not public and i dont think its been used yet | 02:48 |
| LjL | lower dose for a longer time would make sense to me to prevent rebound...' | 02:49 |
| ferret | yea | 02:49 |
| ferret | higher dossages would be bad | 02:49 |
| Tuvix | Careful about the above assumption that the less your immune system fights something off itself the less cell-memory you have. That's very much not how most of our vaccines work today (not just COVID vaccines: all of them.) | 02:50 |
| Tuvix | Dossing is actually a fairly important part of any vaccine trials (before they're shown to work) since you need enough to get a response, but more after the ideal amount required to *induce* long-term cell memory not only has dimminishing returns, but can have other undesirable side-effects. | 02:51 |
| ferret | Tuvix: \o/ | 02:52 |
| ferret | true | 02:52 |
| Tuvix | Vaccines are often multi-dose (eg: COVID, Rabies in pets, countless others given in our youth) specifically because it's the repeated exposure at set intervals that's importnat. More wouldn't be helpful, and would almost surely be harmful. | 02:53 |
| Tuvix | Do too much at once and you may possibly get more of an *immune* response, but that's not what you want: you want durable protection, which means more complex biology is involved such as cell-memory (different types of cells too, namely T- & B-cells) | 02:53 |
| Brainstorm | New from r/Coronavirus: Coronavirus: A Taxonomy of Non-honesty in Public Health Communication → https://old.reddit.com/r/Coronavirus/comments/1237boj/a_taxonomy_of_nonhonesty_in_public_health/ | 04:05 |
| Brainstorm | New from r/Science: science: Life expectancy continues to decline in the U.S. as it rebounds in other countries Life expectancy around the world decreased in 2020 due to COVID-19. Most peer countries rebounded by 2021, while the U.S. continued to decline. → https://old.reddit.com/r/science/comments/123904q/life_expectancy_continues_to_decline_in_the_us_as/ | 05:04 |
| Brainstorm | Updates for New Zealand: +11234 cases since 6 days ago | 05:09 |
| Brainstorm | New from r/Coronavirus: Coronavirus: Should You Get Another Covid Booster? → https://old.reddit.com/r/Coronavirus/comments/1239c7d/should_you_get_another_covid_booster/ | 05:42 |
| ferret | LjL: we made it though the pandemic :D | 07:44 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Vaccination halves risk of long Covid largest study to date shows. Research found that people who had been vaccinated had significantly less risk - almost half the risk - of developing long Covid compared to [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/123d79u/vaccination_halves_risk_of_long_covid_largest/ | 08:55 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | March 27, 2023: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/123efcc/daily_discussion_thread_march_27_2023/ | 09:05 |
| Brainstorm | New from Science-Based Medicine: Autism prevalence increases to 1 in 38, and antivaxxers blame vaccines without using the word “vaccine”: The CDC updated its estimates for the prevalence of autism spectrum disorders. Predictably, antivaxxers blame the increasing [... want %more?] → https://sciencebasedmedicine.org/autism-prevalence-increases-to-1-in-38-and-antivaxxers-blame-vaccines/ | 09:34 |
| Brainstorm | Updates for India: +1805 cases, +6 deaths, +121147 tests since 22 hours ago | 10:02 |
| Brainstorm | New from Reddit (test): CoronavirusUK: Two-thirds of UK workers with long Covid have faced unfair treatment, says report → https://old.reddit.com/r/CoronavirusUK/comments/123i4e1/twothirds_of_uk_workers_with_long_covid_have/ | 12:00 |
| Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 27MAR23 → https://old.reddit.com/r/nCoV/comments/123inwp/global_covid_cases_for_27mar23/ | 12:29 |
| Brainstorm | New from BioNTech: BioNTech Announces Fourth Quarter and Full Year 2022 Financial Results and Corporate Update: Expanded and advanced oncology pipeline to 20 programs in 24 ongoing clinical trials including five ongoing randomized Phase 2 clinical [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/biontech-announces-fourth-quarter-and-full-year-2022-financial | 12:48 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Nuvaxovid, COVID-19 Vaccine (recombinant, adjuvanted), COVID-19 virus infection, Date of authorisation: 20/12/2021, Revision: 8, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/nuvaxovid | 13:58 |
| Brainstorm | New from r/COVID19: Weekly Scientific Discussion Thread - March 27, 2023: This weekly thread is for scientific discussion pertaining to COVID-19. Please post questions about the science of this virus and disease here to collect them for others and clear up post space for [... want %more?] → https://old.reddit.com/r/COVID19/comments/123kxec/weekly_scientific_discussion_thread_march_27_2023/ | 14:08 |
| Brainstorm | New from r/Science: science: Participation in activities such as fitness classes and intramural and drop-in sports before the pandemic was linked to lower levels of stress and higher levels of perceived competence to handle challenges and master school workload during the lockdown. → https://old.reddit.com/r/science/comments/123l2u0/participation_in_activities_such_as_fitness/ | 14:17 |
| Brainstorm | New from Contagion Live: COVID-19 Linked to Long-Term Gastrointestinal Disorders: Data from the US Veterans Affairs found a wide range of gastrointestinal disorders were more likely among patients who had been infected with SARS-CoV-2 within a year after the acute phase of the disease. → https://www.onclive.com/view/covid-19-linked-to-long-term-gastrointestinal-disorders | 14:49 |
| Brainstorm | Updates for Latvia: +71 cases, +323 tests since 3 days ago | 15:07 |
| Brainstorm | New from r/COVID19: COVID19: Examining confidence and hesitancy towards COVID-19 vaccines: A cross-sectional survey using in-person data collection in rural Ghana → https://old.reddit.com/r/COVID19/comments/123m4yl/examining_confidence_and_hesitancy_towards/ | 15:08 |
| Brainstorm | New from COVID on Twitter: Theo Sanderson (@theosanderson): @jcbarret Yeah. I have this feeling that it should somehow be possible to deliver actionable data for substantially less than it ended up costing. It cost ~£1bn. If you did 1,000 tests per week for 3 years that would give you £5,000 per test. → https://twitter.com/theosanderson/status/1640343139608084480 | 15:28 |
| Brainstorm | Updates for Nepal: +25 cases since 23 hours ago | 16:10 |
| Brainstorm | New from StatNews: STAT+: Bernie Sanders’ accidentally great drug pricing idea: At the Senate hearing with Moderna's CEO, Sen. Bernie Sanders put forth a provocative question — and may have alighted on a great drug pricing idea. → https://www.statnews.com/2023/03/27/bernie-sanders-accidentally-great-drug-pricing-idea/ | 16:18 |
| Brainstorm | Updates for Romania: +8082 cases, +37 deaths since 6 days ago | 17:00 |
| Brainstorm | New from r/Coronavirus: Coronavirus: Getting COVID-19 Could Weaken Your Immune System → https://old.reddit.com/r/Coronavirus/comments/123pbdm/getting_covid19_could_weaken_your_immune_system/ | 17:18 |
| LjL | yes, i got the idea that it can do that, by now | 18:13 |
| LjL | %print https://old.reddit.com/r/Coronavirus/comments/123pbdm/getting_covid19_could_weaken_your_immune_system/jdvt5gd/ | 18:13 |
| Brainstorm | LjL, It says: Shamgar65 comments on Getting COVID-19 Could Weaken Your Immune System | 18:13 |
| LjL | "Definitely. I finally got Covid in November for the first time and I’ve had a few normal colds since then that absolutely wrecked me. Usually my colds are mild and I can even go to work. No, I was bed bound for the majority of those days. Maybe 2 or 3 days. Unfortunately, one of those was Christmas weekend :(" | 18:13 |
| LjL | rings a bell | 18:13 |
| LjL | i feel this is also a valid point, if tongue-in-cheek :\ ↓ | 18:14 |
| LjL | 2020: | 18:14 |
| LjL | Me: Guys, what if this virus has some long term AIDS-like effect that we don't know about? | 18:14 |
| LjL | Everyone: Don't be so stupid. Of course not! | 18:14 |
| LjL | 2023: | 18:14 |
| Brainstorm | New from Contagion Live: Risk of Venous Thromboembolism (VTE) Low Among Covid-19 Patients: Risk factors for VTE among COVID-19 patients included age greater than 55 years, male gender, a history of thrombophilia, and obesity. → https://www.onclive.com/view/risk-of-venous-thromboembolism-vte-low-among-covid-19-patients | 18:18 |
| LjL | having a bit of a discussion here... https://np.reddit.com/r/Coronavirus/comments/123pbdm/getting_covid19_could_weaken_your_immune_system/ | 19:30 |
| Brainstorm | New from WebMD: Who Is Most Likely to Get Long COVID? Patient Data May Tell: A review finds that certain groups are more likely to get long COVID, but patients who had at least two COVID vaccine doses had a lower risk of it down the line. → https://www.webmd.com/covid/news/20230327/who-is-most-likely-to-get-long-covid | 19:46 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Brings this piece to mind and that we need to markedly accelerate and quadruple efforts for effective treatments. Much too little is being done.washingtonpost.com/opinions/2023/…#LongCovid twitter.com/loscharlos/sta… pic.twitter.com/hTh6hmDwQd → https://twitter.com/EricTopol/status/1640440745432850432 | 21:53 |
| Brainstorm | Updates for Sri Lanka: +4 cases, +1 deaths since 22 hours ago | 23:02 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): 3) is pure speculation. There is no data for this. SARS-CoV-2 persistence is found in those with weak immunity, but not as a consequence of vaccination! pic.twitter.com/VQUrAzPKZh → https://twitter.com/Marc_Veld/status/1640459351013076992 | 23:10 |
| dTal | LjL: I seem to get sick more easily since catching covid | 23:17 |
| LjL | dTal, you're far from the only one who made this remark to me after having covid :( | 23:18 |
| dTal | however, that might be because catching covid was the catalyst for ending my fairly airtight social isolation, and I'm still "downloading 2 years worth of immune updates@ | 23:18 |
| LjL | i don't know | 23:18 |
| LjL | i just had a few scaremongering comments deleted from a "covid damages your immune systems" thread | 23:19 |
| dTal | what I mean is I get sick more easily than pre-pandemic, but that's not quite a fair comparison | 23:19 |
| LjL | but now i'm not even sure i should have | 23:19 |
| LjL | i understand what you mean | 23:19 |
| dTal | maybe there's more gooing round now too | 23:19 |
| LjL | but i think there are worrying enough signs that people get sick more easily period | 23:19 |
| LjL | not worrying enough maybe to make a reddit thread about it to scare everyone with no good evidence | 23:19 |
| LjL | but when we're just talking... *i* find it likely | 23:20 |
| LjL | it might be due to my generally pessimistic bias | 23:20 |
| dTal | I did share a bed with someone with a cold last thursday, and seem to have avoided getting as ill as she was | 23:20 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): What?? the first coronavirus to ever contain a FCS???HCoV-OC43, HCoV-HKU1, MERS-CoV, and SARS-CoV not? pic.twitter.com/EskXFxnujV → https://twitter.com/Marc_Veld/status/1640462626013495298 | 23:20 |
| dTal | or at all, really | 23:20 |
| dTal | on the other hand, I was miserably ill last weekend, so maybe it was the same virus and I got lucky with immunity | 23:21 |
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