libera/##covid-19/ Sunday, 2023-08-20

BrainstormNew from r/Coronavirus: Coronavirus: Why Blood Type Seems to Be Linked With COVID-19 Risk → https://old.reddit.com/r/Coronavirus/comments/15vsx5q/why_blood_type_seems_to_be_linked_with_covid19/00:09
Vyrusnice to see this working again. A few weeks ago I was looking for a powered respirator with HEPA, but all I could find was welding respirators etc, anyone know of a good PAPR deal for under 1000$ ? I'm now sure this sh1t is not going anywhere or it's not going to get weaker, and I dont want to get vaccinated either, I want to invest more in not contracting the virus at all... wouldn't hurt wearing a space suit to the supermarket once in a blue moon when we01:54
Vyrus are close to the peak of a bad wave01:54
VyrusI already have particle sensors that can detect down to 0.01 microns. All we need is positive air pressure and a HEPA-13 type filter with powered respirators. The answer is so simple lol01:58
BrainstormNew from This Week In Virology: TWiV 1037: Antibodies, the good (CoV), the bad (Ad), the beautiful: TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored [... want %more?] → https://www.microbe.tv/twiv/twiv-1037/06:16
BrainstormNew from r/Coronavirus: Weekly Discussion Thread | Week of August 20, 2023: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/15w47o0/weekly_discussion_thread_week_of_august_20_2023/09:09
BrainstormNew from Contagion Live: This Week's News In Infectious Disease: This week: the FDA accepts NDA for investigational antibiotic; mRNA COVID-19 vaccines update protections; counseling families on nirsevimab; and how antibiotic actions on gut microbes of patients might affect the microbiome of housemates. → https://www.contagionlive.com/view/this-week-s-news-in-infectious-disease11:43
BrainstormNew from r/Science: science: Severe COVID-19 infection triggers changes that affect gene expression in immune system stem cells, causing long-lasting alterations in the body’s immune response. The finding could help explain symptoms of prolonged inflammation and “long [... want %more?] → https://old.reddit.com/r/science/comments/15w8wg3/severe_covid19_infection_triggers_changes_that/13:30
Vyrus^ hyper activation of monocytes hmmmm. I was randomly reading about taurine and it's immunomodulatory effects and how it downregulated monocytes... I wonder....15:00
Vyrushow long are these epigenetic changes, I wish it wasn't a paid print so we could read the discussion or the details15:01
Vyrus"Alterations in innate immune phenotypes and epigenetic programs of HSPC persisted for months to 1 year following severe COVID-19 and were associated with distinct transcription factor (TF) activities, altered regulation of inflammatory programs, and durable increases in myelopoiesis"15:03
Vyrusthats not too bad, but it's quite long for a chronic inflammation15:04
Vyrustranslates to exhaustion of native immune system and especially T-cells, means faster progress of cancer and many other things (imagine trying to prove this over 10 years though)15:10
VyrusI simply suggest we all switch to a ketogenic diet and an anti-inflammatory lifestyle. More fish, more exercise and more sleep ! lol15:12
BrainstormNew from r/Coronavirus: Coronavirus: How Nursing Homes Failed to Protect Residents From Covid → https://old.reddit.com/r/Coronavirus/comments/15wazxl/how_nursing_homes_failed_to_protect_residents/15:15
Vyrusalso consider - older human bodies are more prone to inflammation, so this is like throwing a molotov cocktail into a bonfire. But thinking very young people are less affected could also be false, younger bodies and immune systems are in a learning phase, messing with epigenetics in this phase screws up that phase aaaand potentially has very, very long term consequences. But if they're not getting serious COVID, then maybe they're fine, right. Research15:49
Vyrus concludes this on serious cases, it seems ?15:49
Vyrushere , I found the same study, but the content is juicier, goes wway deeper into it  https://www.biorxiv.org/content/10.1101/2022.02.09.479588v1.full15:50
Vyrusand that one concludes Durable Reprogramming of HSPC Transcriptomes also happens with mild forms of COVID15:50
Vyrusyou guys think, things go back to baseline after even the 2-12 months that they've studied ? Hell no. They say, "for up to one year into late convalescence following severe COVID-19, AP-1 activity returns to, or below, baseline, while IRF factor activity remains elevated." Notice the "remains elevated" part? It's like they're waving a flag saying, "Hey, something's still going on here!" They don't say it's completely resolved, and the part about "persisting16:03
Vyrus IRF chromatin binding activity post-COVID-19" makes it sound like there's still some action happening.16:03
Vyrusok, I'm done contributing to discussion, I won't read these again - this is bad enough, I want to go back to living my life lol. Bye16:04
BrainstormNew from r/COVID19: COVID19: Pathophysiology, diagnosis, and management of neuroinflammation in covid-19 → https://old.reddit.com/r/COVID19/comments/15wclq5/pathophysiology_diagnosis_and_management_of/16:22
BrainstormNew from r/COVID19: COVID19: Phase III Pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin ) → https://old.reddit.com/r/COVID19/comments/15wddnp/phase_iii_pivotal_comparative_clinical_trial_of/16:51
BrainstormNew from Reddit (test): nCoV: Mortality Trends Raise Underwriting Questions For Life Insurers | 20AUG23 → https://old.reddit.com/r/nCoV/comments/15wfap3/mortality_trends_raise_underwriting_questions_for/18:17
LjLTesting bridge again, it's temperamental...18:30
BrainstormNew from r/Science: science: Meditation practice may be helpful to people suffering from existential isolation → https://old.reddit.com/r/science/comments/15wj0aq/meditation_practice_may_be_helpful_to_people/20:40
BrainstormNew from Outbreak News Today: Colombia: ‘We are in an epidemic year for Dengue’: NewsDesk @bactiman63 The National Institute of Health explains the dengue figures in Colombia that correspond to the behavior of an epidemic year,  which occurs every three to four years.  and makes [... want %more?] → https://outbreaknewstoday.com/colombia-we-are-in-an-epidemic-year-for-dengue-65879/21:48
BrainstormNew from r/COVID19: COVID19: Effectiveness of Monovalent and Bivalent mRNA Vaccines in Preventing COVID-19–Associated Emergency Department and Urgent Care Encounters Among Children Aged 6 Months–5 Years — VISION Network, United States, July 2022–June 2023 → https://old.reddit.com/r/COVID19/comments/15wlx67/effectiveness_of_monovalent_and_bivalent_mrna/22:36

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