| Brainstorm | New from r/Coronavirus: Coronavirus: Rise in COVID, flu and RSV prompts Bay Area health recommendations — including masking → https://old.reddit.com/r/Coronavirus/comments/189jfrn/rise_in_covid_flu_and_rsv_prompts_bay_area_health/ | 03:42 |
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| Brainstorm | New from This Week In Virology: TWiV 1067: Heads or tails, you win a phage lunch: On this all-bacteriophage episode, TWiV explains the ‘vampire phage’, and and how mammalian cells internalize phage particles and utilize them to enhance cell growth and survival. → https://www.microbe.tv/twiv/twiv-1067/ | 06:13 |
| Brainstorm | New from r/Coronavirus: Weekly Discussion Thread | Week of December 03, 2023: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/189otmv/weekly_discussion_thread_week_of_december_03_2023/ | 09:04 |
| Brainstorm | New from r/WorldNews: worldnews: Deadly COVID Strain Killing Cats in Cyprus and the UK → https://old.reddit.com/r/worldnews/comments/189qaek/deadly_covid_strain_killing_cats_in_cyprus_and/ | 11:08 |
| Brainstorm | New from PubMed: Platypnea-Orthodeoxia Syndrome Caused by Patent Foramen Ovale with Right-To-Left Shunt: BACKGROUND Patent Foramen Ovale (PFO) is an important part of fetal circulation. It allows the oxygenated blood from the umbilical cord to bypass the lungs. PFOs usually close after birth due to the sudden change of the [... want %more?] → https://pubmed.ncbi.nlm.nih.gov/38042984/ | 12:43 |
| Brainstorm | New from NPR Science: Feeling alone? 5 tips to create connection and combat loneliness: We all feel lonely at some point, but long-term social isolation can damage our mental and physical health. A new book called Project UnLonely shows how [... want %more?] → https://www.npr.org/sections/health-shots/2023/12/03/1216617723/loneliness-connection-social-isolation-community-project-unlonely | 13:13 |
| Brainstorm | New from Marc Veldhoen on Mastodon: (news): Vaccines work best, especially in vulnerable populations, when regularly updated to match the then-circulation pathogen variants to catch the constantly mutating viruses that escape neutralising antibodies, as early as possible. → https://mastodon.online/@marc_veld/111516938244581000 | 15:26 |
| Brainstorm | New from Contagion Live: Not All Immunocompromised Patients Are at Risk for Prolonged COVID-19 Infection: A study offers a glimpse into what populations may be more likely to suffer a prolonged infection and may need to be prospectively followed for [... want %more?] → https://www.contagionlive.com/view/not-all-immunocompromised-patients-are-at-risk-for-prolonged-covid-19-infection | 18:38 |
| Brainstorm | New from r/COVID19: COVID19: Persistent immune imprinting after XBB.1.5 COVID vaccination in humans → https://old.reddit.com/r/COVID19/comments/189yrh1/persistent_immune_imprinting_after_xbb15_covid/ | 18:47 |
| Brainstorm | New from r/Coronavirus: Coronavirus: The Disparate Territorial Impact of SARS-CoV-2 & How Nations Respond → https://old.reddit.com/r/Coronavirus/comments/189zkfs/the_disparate_territorial_impact_of_sarscov2_how/ | 19:26 |
| LjL | de-facto, ublx: i don't like the sound of that persistent immune imprinting paper even though i don't even really understand the abstract. but looks like the XBB.1.5 shots increases antibody titers against earlier variants, but doesn't actually cause the production of any XBB.1.5 specific antibodies (at least not one dose) | 19:41 |
| de-facto | LjL, hmm wouldnt that also depend on the immunologic history of each such cases, e.g. if their immune system was allowed to have long enough "pauses" in between to partially forget the old versions and mobilize enough naive new cells to sufficiently adapt to the newer aspects of more recent variants? | 19:50 |
| de-facto | (at least that is my naive imagination of it) | 19:50 |
| LjL | de-facto, i don't know, my understanding of original antigenic sin is that it's "permanent" | 19:53 |
| de-facto | afaik the B-cells underwent multiple generations of "fine tuning" and selection during the "cool down period" after the antigenic exposure stopped | 19:53 |
| de-facto | i think there should be an evolutionary advantage for immune systems that are able to adapt de-novo on the natural cycle of repeated antigen exposure of seasonal viruses that naturally only re-occur with sufficient antigenic drift | 19:54 |
| LjL | "These results indicate that immune imprinting persists even after multiple exposures to Omicron spikes through vaccination and infection" ← so i guess they're saying there have been already a few exposures that should have resulted in new antibodies but haven't | 19:55 |
| ublx | well that's just lovely | 19:56 |
| LjL | de-facto, well clearly there is also some advantage in using the antibodies you already have, or the original antigenic sin wouldn't be a thing (and it is a thing, maybe dubiously in COVID, but it exists as a thing in other diseases) | 19:56 |
| de-facto | my point being that it may be very important no NOT have antigenic exposure at the time period directly prior to the exposure to a new antigenic variant in order for the immune system to sufficiently adapt | 19:56 |
| de-facto | (i am not sure of that, but thats how i imagine this) | 19:57 |
| LjL | "To investigate this further, we depleted polyclonal plasma antibodies recognizing the Wuhan-Hu-1 S trimer and assessed binding titers against the Wuhan-Hu-1 S and XBB.1.5 S ectodomain trimers using ELISAs. As expected, no antibodies binding to Wuhan-Hu-1 S were detected after depletion. Moreover, depletion of antibodies targeting Wuhan-Hu-1 S entirely abrogated binding to XBB.1.5 S except for two individuals for which binding titers decreased 10-fold" | 19:58 |
| LjL | So they are saying that after they got rid of antibodies that bound to the original strain, none were left that bound to XBB.1.5! | 19:58 |
| LjL | People on r/COVID19 can say all they want about the title being unsavory and presented wrongly, but... this isn't good news, is it? | 19:59 |
| LjL | de-facto, i think most people waited like about a year between the last omicron+original jab, and the current XBB.1.5 jab | 20:01 |
| LjL | is a year not enough | 20:02 |
| LjL | i guess it should be taken into account that this study only looked at serum from 12 people, if i understand it right | 20:03 |
| de-facto | " the XBB.1.5 mutations or the BA.2.86 | 20:03 |
| de-facto | mutations using plasma obtained 7 to 13 days (mean: 9.7 days) after vaccination with the | 20:03 |
| de-facto | XBB.1.5 S mRNA booster" <-- also that is very short, does that even allow new generations of antibodies to develop? | 20:03 |
| LjL | if that's actually when they took the serum, it does seem a bit short | 20:04 |
| de-facto | afaik the original (naive) immune systems took like two weeks to develop the original antibodies from scatch | 20:05 |
| de-facto | so it would make somewhat sense that the first antibodies released into serum after exposure to a new antigenic variant would be those from the already existing B-cells (aka the old variants) | 20:05 |
| de-facto | e.g. the spectrum probably changes over time, when also some new generations begin to contribute? | 20:06 |
| Brainstorm | New from Politico: Politics at Jack and Sam’s: The Week … Boris Johnson at the COVID inquiry → https://www.politico.eu/podcast/the-week-boris-johnson-at-the-covid-inquiry/ | 20:52 |
| Brainstorm | New from Marc Veldhoen on Mastodon: (news): Existing memory B cells can mutate their antibody genes and reselect the best new ones. These will be stored again as memory B cells. Collectively, the virus will be recognised, contained and cleared, preventing severe disease. → https://mastodon.online/@marc_veld/111518763210779070 | 23:12 |
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