libera/##covid-19/ Wednesday, 2023-12-06

BrainstormNew from Reddit (test): CoronavirusUK: Long Covid ‘changes brains of people differently to those who recover from virus’ → https://old.reddit.com/r/CoronavirusUK/comments/18bozy1/long_covid_changes_brains_of_people_differently/00:03
de-factohoping she will be better soon00:50
de-facto%title https://press.rsna.org/timssnet/media/pressreleases/14_pr_target.cfm?id=248101:02
Brainstormde-facto: From press.rsna.org: Novel MRI Reveals Brain Changes in Long-COVID Patients01:02
LjLde-facto, the problem is that some novel MRI (possibly the same, can't read it now) was found to reveal brain changes in *both* long COVID patients and in people who had simply had COVID :(01:23
de-factoyes01:24
de-factounfortunately it looks like this may be much more wide spread than what we initially thought01:24
LjLde-facto, https://www.eurekalert.org/news-releases/1008223 is the one I saw I think01:26
LjLyeah it's the same, RSNA01:26
LjLi'll prefer to just think they want to show off their latest MRI techniques :P01:27
* LjL plugs his ears01:27
de-facto%title https://www.mdpi.com/1999-4915/14/7/141501:27
Brainstormde-facto: From www.mdpi.com: Viruses | Free Full-Text | Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human Proteins01:27
de-facto%title https://www.biorxiv.org/content/10.1101/2023.04.04.535604v101:27
Brainstormde-facto: From www.biorxiv.org: SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 | bioRxiv01:28
de-facto%title https://www.mdpi.com/1873-149X/29/3/3901:28
Brainstormde-facto: From www.mdpi.com: Pathophysiology | Free Full-Text | Molecular Mimicry between SARS-CoV-2 and Human Endocrinocytes: A Prerequisite of Post-COVID-19 Endocrine Autoimmunity?01:28
LjLshush don't get the anti-vax going with the damn spike :P01:28
LjLor me! i'm due for my booster, err, tomorrow01:28
LjLmeaning the 7th01:28
LjLnot particularly looking forward to it, but hey at least i'll get it... like about 2% of Italians or so01:29
BrainstormNew from Eric Topol on Mastodon: LongCovid: "These results robustly demonstrate pronounced cognitive slowing in people with PCC [ # LongCovid ] which distinguishes them from age-matched healthy individuals who previously had symptomatic COVID-19 but did not manifest Long Covid." https:// medrxiv.org/content/10.1101/20 23.12.03.23299331v1 → https://mstdn.social/@erictopol/11153060367610066201:29
de-factoLjL, what type of booster did you register for?01:29
LjLno choice is given01:29
LjLbut we mostly have BioNTech/Pfizer01:29
de-factoor what do you expect them to offer you there?01:30
de-factoany info on that01:30
de-factoi am a bit out of the loop01:30
LjLthey're all XBB.1.5 based01:30
de-factoXBB.1.5 signature?01:30
de-factooh i see01:30
LjLmonovalent on that01:30
de-factoyeah01:30
LjLi believe we have Pfizer/BNT and a little bit of Novavax01:30
de-factowhen was your last known exposure to spike?01:30
LjLI'd rather have the former since that's what I always had and it gave me no side effects01:30
LjLhmm01:30
LjLlet me get my certificate01:31
de-facto%title https://www.medrxiv.org/content/10.1101/2023.12.03.23299331v101:31
Brainstormde-facto: From www.medrxiv.org: Long COVID is associated with severe cognitive slowing | medRxiv01:31
LjL01:33
LjL1 - Data: 05/06/202101:33
LjLDettagli: SARS-CoV-2 / COMIRNATY01:33
LjL2 - Data: 08/07/202101:33
LjLDettagli: SARS-CoV-2 / COMIRNATY01:33
LjL3 - Data: 05/12/202101:33
LjLDettagli: SARS-CoV-2 / COMIRNATY01:33
LjL4 - Data: 07/10/202201:33
LjLDettagli: SARS-CoV-2 / COMIRNATY01:33
de-factook so more than a year then01:36
de-factowell thats the usual for annually circulating seasonal respiratory pathogens01:37
LjLyeah, i would have appreciated it if this year's was also in October and not f'ing December01:37
LjLespecially given there is no big rush to get them at all for most people, so they COULD have given them earlier to people who WANTED them01:38
LjLbut whatever, it is what it is01:38
de-factoyeah01:40
de-factodo you have to pay for it yourself?01:40
LjLno01:47
LjLbut at first only fragile people (elderly etc) were eligible01:47
LjLthen they saw nobody was taking it, so they opened it up to everyone01:47
LjLbut it took them a good while to "realize"01:47
LjLalso, i'll get it at a pharmacy, inoculated by the pharmacist01:48
LjLi'll be honest - i am a bit apprehensive about that01:48
LjLall the other ones, i got at a vaccine center, with doctors and nurses01:48
LjLbut it doesn't exist anymore01:48
LjLthe pharmacist supposedly had to follow a brief course to be able to give COVID jabs01:48
LjLbut still... i imagine it was *brief*01:48
BrainstormNew from StatNews: STAT+: Pfizer plans to depart BIO: The pharmaceutical giant Pfizer plans to exit the Biotechnology Innovation Organization, the latest in a string of major departures from industry trade groups. → https://www.statnews.com/2023/12/05/pfizer-plans-to-depart-bio/02:45
BrainstormNew from r/WorldNews: worldnews: German accused of founding armed group to fight COVID rules: Prosecutors said a German man has been arrested in Portugal on suspicion of forming an armed group to oppose COVID-19 measures. The man reportedly believed the rules were being [... want %more?] → https://old.reddit.com/r/worldnews/comments/18bumar/german_accused_of_founding_armed_group_to_fight/04:38
BrainstormNew from r/Coronavirus: Coronavirus: German accused of founding armed group to fight COVID rules → https://old.reddit.com/r/Coronavirus/comments/18bwyxl/german_accused_of_founding_armed_group_to_fight/06:40
BrainstormNew from BMJ: Cosmetic surgeon is struck off for dishonesty and as a risk to patient safety: A cosmetic surgeon has been struck off the UK medical register after a tribunal found that he deliberately misled the Care Quality Commission (CQC) about procedures he was performing at his clinics. Ashish Dutta also worked in breach [... want %more?] → http://www.bmj.com/content/383/bmj.p2882.short09:47
BrainstormNew from BMJ: Cosmetic surgeon is struck off for dishonesty and as a risk to patient safety: A cosmetic surgeon has been struck off the UK medical register after a tribunal found that he deliberately misled the Care Quality Commission (CQC) about procedures he was performing at his clinics. Ashish Dutta also worked in breach [... want %more?] → http://www.bmj.com/content/383/bmj.p2882.short09:47
BrainstormNew from Politico: Boris Johnson hit by protests as he says sorry for UK’s COVID-19 ‘pain’: Four protesters — who were quiet, but holding signs aimed at Johnson — were removed from the COVID-19 inquiry. → https://www.politico.eu/article/boris-johnson-hit-by-protests-as-he-apologizes-for-uks-covid-19-pain/11:32
BrainstormNew from r/COVID19: COVID19: Remission of severe forms of long COVID following monoclonal antibody (MCA) infusions: A report of signal index cases and call for targeted research → https://old.reddit.com/r/COVID19/comments/18c1gyi/remission_of_severe_forms_of_long_covid_following/12:00
BrainstormNew from Marc Veldhoen on Mastodon: (news): This highlights the importance of local immunity against infection (vaccine-induced, immunity will protect against disease, but its local protection against infection is much less) and why nasal vaccines may help against infection. But, antibodies wane and the virus mutates. → https://mastodon.online/@marc_veld/11153317163242776512:19
BrainstormNew from r/Coronavirus: Coronavirus: Erie County Health Department says to take preventive measures against COVID amid rise in cases and deaths → https://old.reddit.com/r/Coronavirus/comments/18c23ja/erie_county_health_department_says_to_take/12:58
BrainstormNew from r/Coronavirus: Coronavirus: Updated Novavax COVID-19 shot approved by Health Canada → https://old.reddit.com/r/Coronavirus/comments/18c29qu/updated_novavax_covid19_shot_approved_by_health/13:37
BrainstormNew from Politico: Boris Johnson’s COVID inquiry grilling: all the bombshell moments: Britain's former prime minister is facing a two-day going-over by the country's official pandemic probe. POLITICO is tracking the key moments. → https://www.politico.eu/article/boris-johnson-covid-19-inquiry-hearing-grilling-big-moments-pandemic/14:16
BrainstormNew from StatNews: Pharma: STAT+: Pharmalittle: Pfizer is leaving the BIO trade group; CVS drug-pricing plan may not lower costs for consumers → https://www.statnews.com/pharmalot/2023/12/06/bio-pfizer-cvs-merck-novartis-lilly-novo-wegovy-obesity-weight-loss/15:23
BrainstormNew from r/Science: science: Sars Cov 2 may induce igg4 synthesis to evade the immune system → https://old.reddit.com/r/science/comments/18c508j/sars_cov_2_may_induce_igg4_synthesis_to_evade_the/16:21
BrainstormNew from BMJ: Districts of Pakistan boycott polio immunisation until economic and health demands are met: Tribal elders in the last remaining areas of Pakistan to have endemic wild polio are boycotting immunisation campaigns until the country’s government meets demands on infrastructure, livelihoods, and health.Various [... want %more?] → http://www.bmj.com/content/383/bmj.p2890.short16:51
BrainstormNew from Marc Veldhoen on Mastodon: (news):   The paper shows this happens with the mRNA vaccines in ~8% of the protein made. That means 92% is Spike and 8% is part Spike but does not end with it. These new proteins are recognised by our immune system and T cells responding to them are present in vaccinated people. → https://mastodon.online/@marc_veld/11153437174200138517:21
BrainstormNew from Marc Veldhoen on Mastodon: (news): Note 1, previous work did not detect frameshifts/altered protein length https://www. nature.com/articles/s41586-021 -03275-y/figures/5 , staining with S1-specific antibody. The proteins from a frameshift may be too limited to detect. → https://mastodon.online/@marc_veld/11153439880917031017:31
BrainstormNew from BBC Health: Covid study: mRNA vaccines could be fine-tuned: The revolutionary technology could be updated for even greater accuracy, research suggests. → https://www.bbc.co.uk/news/health-6762518017:40
BrainstormNew from BMJ Open: Estimating the frequency of inpatient adverse events using a two-step retrospective chart review: a study protocol: Introduction Adverse events are a major cause of patient harm in the hospitalised setting. Low-income and middle-income countries account for a disproportionate share of the global [... want %more?] → http://bmjopen.bmj.com/cgi/content/short/13/12/e07697118:00
BrainstormNew from StatNews: ‘Last roll of the dice’ for a near-term HIV vaccine fails: PrEPVacc was one of the first large, African-led HIV vaccine trials and one of the first trials to incorporate PrEP. Now it's shutting down, and no other vaccine trials are… → https://www.statnews.com/2023/12/06/aids-hiv-vaccine-fail-prepvacc-africa/18:39
BrainstormNew from BBC Health: I should have twigged Covid risk earlier, admits Boris Johnson: The former PM tells the pandemic inquiry he initially underestimated the challenge posed by the virus. → https://www.bbc.co.uk/news/uk-politics-6763981318:58
BrainstormNew from r/Coronavirus: Coronavirus: Covid study: mRNA vaccines could be fine-tuned → https://old.reddit.com/r/Coronavirus/comments/18cc7y6/covid_study_mrna_vaccines_could_be_finetuned/21:26
BrainstormNew from r/Coronavirus: Coronavirus: Home Test to Treat program extends nationwide: Program now offers testing, telehealth and treatment for COVID-19 and flu → https://old.reddit.com/r/Coronavirus/comments/18cdv4k/home_test_to_treat_program_extends_nationwide/22:25
BrainstormNew from Reddit (test): CoronavirusUK: SARS-CoV-2 genome sequence prevalence and growth rate update: 6 December 2023 → https://old.reddit.com/r/CoronavirusUK/comments/18cg178/sarscov2_genome_sequence_prevalence_and_growth/23:34

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